Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

Yukinori Okada; Xueling Sim; Min Jin Go; Jer-yuarn Wu; Dongfeng Gu; Fumihiko Takeuchi; Atsushi Takahashi; Shiro Maeda; Tatsuhiko Tsunoda; Peng Chen; Su-chi Lim; Tien-yin Wong; Jianjun Liu; Terri L Young; Tin Aung; Mark Seielstad; Yik-ying Teo; Young Jin Kim; Jong-young Lee; Bok-ghee Han; Daehee Kang; Chien-hsiun Chen; Fuu-jen Tsai; Li-ching Chang; S-j Cathy Fann; Hao Mei; Dabeeru C Rao; James E Hixson; Shufeng Chen; Tomohiro Katsuya; Masato Isono; Toshio Ogihara; John C Chambers; Weihua Zhang; Jaspal S Kooner; Eva Albrecht; Kazuhiko Yamamoto; Michiaki Kubo; Yusuke Nakamura; Naoyuki Kamatani; Norihiro Kato; Jiang He; Yuan-tsong Chen; Yoon Shin Cho; E-shyong Tai; Toshihiro Tanaka; Graham Lord

doi:10.1038/ng.2352

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

Yukinori Okada, Xueling Sim, Min Jin Go, Jer-yuarn Wu, Dongfeng Gu, Fumihiko Takeuchi, Atsushi Takahashi, Shiro Maeda, Tatsuhiko Tsunoda, Peng Chen, Su-chi Lim, Tien-yin Wong, Jianjun Liu, Terri L Young, Tin Aung, Mark Seielstad, Yik-ying Teo, Young Jin Kim, Jong-young Lee, Bok-ghee HanDaehee Kang, Chien-hsiun Chen, Fuu-jen Tsai, Li-ching Chang, S-j Cathy Fann, Hao Mei, Dabeeru C Rao, James E Hixson, Shufeng Chen, Tomohiro Katsuya, Masato Isono, Toshio Ogihara, John C Chambers, Weihua Zhang, Jaspal S Kooner, Eva Albrecht, Kazuhiko Yamamoto, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Norihiro Kato, Jiang He, Yuan-tsong Chen, Yoon Shin Cho, E-shyong Tai, Toshihiro Tanaka, Graham Lord (Collaborator)

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Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10−8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function–related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Original language	English
Pages (from-to)	904-909
Journal	Nature Genetics
Volume	44
Issue number	8
DOIs	https://doi.org/10.1038/ng.2352
Publication status	Published - 15 Jul 2012

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Okada, Y., Sim, X., Go, M. J., Wu, J., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S., Wong, T., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y., Kim, Y. J., Lee, J., ... Lord, G. (2012). Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations. Nature Genetics, 44(8), 904-909. https://doi.org/10.1038/ng.2352

@article{21aea9afa6fc4ec887c5ac534a243af1,

title = "Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations",

abstract = "Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10−8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function–related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.",

author = "Yukinori Okada and Xueling Sim and Go, {Min Jin} and Jer-yuarn Wu and Dongfeng Gu and Fumihiko Takeuchi and Atsushi Takahashi and Shiro Maeda and Tatsuhiko Tsunoda and Peng Chen and Su-chi Lim and Tien-yin Wong and Jianjun Liu and Young, {Terri L} and Tin Aung and Mark Seielstad and Yik-ying Teo and Kim, {Young Jin} and Jong-young Lee and Bok-ghee Han and Daehee Kang and Chien-hsiun Chen and Fuu-jen Tsai and Li-ching Chang and Fann, {S-j Cathy} and Hao Mei and Rao, {Dabeeru C} and Hixson, {James E} and Shufeng Chen and Tomohiro Katsuya and Masato Isono and Toshio Ogihara and Chambers, {John C} and Weihua Zhang and Kooner, {Jaspal S} and Eva Albrecht and Kazuhiko Yamamoto and Michiaki Kubo and Yusuke Nakamura and Naoyuki Kamatani and Norihiro Kato and Jiang He and Yuan-tsong Chen and Cho, {Yoon Shin} and E-shyong Tai and Toshihiro Tanaka and Graham Lord",

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doi = "10.1038/ng.2352",

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Okada, Y, Sim, X, Go, MJ, Wu, J, Gu, D, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, S, Wong, T, Liu, J, Young, TL, Aung, T, Seielstad, M, Teo, Y, Kim, YJ, Lee, J, Han, B, Kang, D, Chen, C, Tsai, F, Chang, L, Fann, SC, Mei, H, Rao, DC, Hixson, JE, Chen, S, Katsuya, T, Isono, M, Ogihara, T, Chambers, JC, Zhang, W, Kooner, JS, Albrecht, E, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, J, Chen, Y, Cho, YS, Tai, E, Tanaka, T & Lord, G 2012, 'Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations', Nature Genetics, vol. 44, no. 8, pp. 904-909. https://doi.org/10.1038/ng.2352

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AU - Sim, Xueling

AU - Go, Min Jin

AU - Wu, Jer-yuarn

AU - Gu, Dongfeng

AU - Takeuchi, Fumihiko

AU - Takahashi, Atsushi

AU - Maeda, Shiro

AU - Tsunoda, Tatsuhiko

AU - Chen, Peng

AU - Lim, Su-chi

AU - Wong, Tien-yin

AU - Liu, Jianjun

AU - Young, Terri L

AU - Aung, Tin

AU - Seielstad, Mark

AU - Teo, Yik-ying

AU - Kim, Young Jin

AU - Lee, Jong-young

AU - Han, Bok-ghee

AU - Kang, Daehee

AU - Chen, Chien-hsiun

AU - Tsai, Fuu-jen

AU - Chang, Li-ching

AU - Fann, S-j Cathy

AU - Mei, Hao

AU - Rao, Dabeeru C

AU - Hixson, James E

AU - Chen, Shufeng

AU - Katsuya, Tomohiro

AU - Isono, Masato

AU - Ogihara, Toshio

AU - Chambers, John C

AU - Zhang, Weihua

AU - Kooner, Jaspal S

AU - Albrecht, Eva

AU - Yamamoto, Kazuhiko

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Kamatani, Naoyuki

AU - Kato, Norihiro

AU - He, Jiang

AU - Chen, Yuan-tsong

AU - Cho, Yoon Shin

AU - Tai, E-shyong

AU - Tanaka, Toshihiro

A2 - Lord, Graham

PY - 2012/7/15

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N2 - Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10−8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function–related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

AB - Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10−8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function–related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

U2 - 10.1038/ng.2352

DO - 10.1038/ng.2352

M3 - Article

SN - 1061-4036

VL - 44

SP - 904

EP - 909

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

Abstract

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