Meta-analysis of minimally invasive internal thoracic artery bypass versus percutaneous revascularisation for isolated lesions of the left anterior descending artery

Omer Aziz, Christopher Rao, Sukhmeet Singh Panesar, Catherine Jones, Stephen Morris, Ara Darzi, Thanos Athanasiou

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To compare outcomes between minimally invasive left internal thoracic artery bypass and percutaneous coronary artery stenting as primary interventions for isolated lesions of the left anterior descending artery.

DESIGN: Meta-analysis of randomised and non-randomised comparative peer reviewed publications.

DATA SOURCES: Embase, Medline, Cochrane, Google Scholar, and Health Technology Assessment databases (1966-2005).

REVIEW METHODS: Studies comparing the two procedures as the primary intervention for isolated left anterior descending artery stenosis were identified and the following extracted: study design, population characteristics, severity of coronary artery disease, cardiovascular risk factors, and outcomes of interest.

RESULTS: 12 studies (1952 patients) reporting results from eight groups were included: one was a retrospective design, one prospective non-randomised, and six prospective randomised. Meta-analysis of randomised trials showed a higher rate of recurrence of angina (odds ratio 2.62, 95% confidence interval 1.32 to 5.21), incidence of major adverse coronary and cerebral events (2.86, 1.62 to 5.08), and need for repeat revascularisation (4.63, 2.52 to 8.51) with percutaneous stenting. No significant difference was found in myocardial infarction, stroke, or mortality at maximum follow-up between interventions.

CONCLUSIONS: Minimally invasive left internal thoracic artery bypass for isolated lesions of the left anterior descending artery resulted in fewer complications in the mid-term compared with percutaneous transluminal coronary artery stenting.

Original languageEnglish
Pages (from-to)617
Number of pages1
JournalBMJ (Clinical Research Edition)
Volume334
Issue number7594
DOIs
Publication statusPublished - 24 Mar 2007

Keywords

  • Angina Pectoris/surgery
  • Clinical Trials as Topic
  • Coronary Artery Bypass/methods
  • Coronary Artery Disease/surgery
  • Humans
  • Internal Mammary-Coronary Artery Anastomosis/methods
  • Minimally Invasive Surgical Procedures/methods
  • Myocardial Infarction/etiology
  • Myocardial Revascularization/methods
  • Postoperative Complications/etiology
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Stents
  • Stroke/etiology
  • Treatment Outcome

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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