Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Richard S. Houlston; Jeremy Cheadle; Sara E. Dobbins; Albert Tenesa; Angela M. Jones; Kimberley Howarth; Sarah L. Spain; Peter Broderick; Enric Domingo; Susan Farrington; James G D Prendergast; Alan M. Pittman; Evi Theodoratou; Christopher G. Smith; Bianca Olver; Axel Walther; Rebecca A. Barnetson; Michael Churchman; Emma E M Jaeger; Steven Penegar; Ella Barclay; Lynn Martin; Maggie Gorman; Rachel Mager; Elaine Johnstone; Rachel Midgley; Iina Niittymäki; Sari Tuupanen; James Colley; Shelley Idziaszczyk; Huw J W Thomas; Anneke M. Lucassen; D. Gareth R Evans; Eamonn R. Maher; Timothy Maughan; Antigone Dimas; Emmanouil Dermitzakis; Jean Baptiste Cazier; Lauri A. Aaltonen; Paul Pharoah; David J. Kerr; Luis G. Carvajal-Carmona; Harry Campbell; Malcolm G. Dunlop; Ian P M Tomlinson

doi:10.1038/ng.670

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Richard S. Houlston, Jeremy Cheadle, Sara E. Dobbins, Albert Tenesa, Angela M. Jones, Kimberley Howarth, Sarah L. Spain, Peter Broderick, Enric Domingo, Susan Farrington, James G D Prendergast, Alan M. Pittman, Evi Theodoratou, Christopher G. Smith, Bianca Olver, Axel Walther, Rebecca A. Barnetson, Michael Churchman, Emma E M Jaeger, Steven PenegarElla Barclay, Lynn Martin, Maggie Gorman, Rachel Mager, Elaine Johnstone, Rachel Midgley, Iina Niittymäki, Sari Tuupanen, James Colley, Shelley Idziaszczyk, Huw J W Thomas, Anneke M. Lucassen, D. Gareth R Evans, Eamonn R. Maher, Timothy Maughan, Antigone Dimas, Emmanouil Dermitzakis, Jean Baptiste Cazier, Lauri A. Aaltonen, Paul Pharoah, David J. Kerr, Luis G. Carvajal-Carmona, Harry Campbell, Malcolm G. Dunlop, Ian P M Tomlinson

Research output: Contribution to journal › Article › peer-review

Abstract

Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55-10-10 and rs6687758, OR = 1.09, P = 2.27-10-9), 3q26.2 (rs10936599, OR = 0.93, P = 3.39-10-8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89-10-10 and rs7136702, OR = 1.06, P = 4.02-10 -8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89-10-10). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. © 2010 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	973-977
Number of pages	4
Journal	Nature Genetics
Volume	42
Issue number	11
DOIs	https://doi.org/10.1038/ng.670
Publication status	Published - Nov 2010

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Houlston, R. S., Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., Spain, S. L., Broderick, P., Domingo, E., Farrington, S., Prendergast, J. G. D., Pittman, A. M., Theodoratou, E., Smith, C. G., Olver, B., Walther, A., Barnetson, R. A., Churchman, M., Jaeger, E. E. M., ... Tomlinson, I. P. M. (2010). Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nature Genetics, 42(11), 973-977. https://doi.org/10.1038/ng.670

@article{8af8d0626a59462580999030623af571,

title = "Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33",

abstract = "Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55-10-10 and rs6687758, OR = 1.09, P = 2.27-10-9), 3q26.2 (rs10936599, OR = 0.93, P = 3.39-10-8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89-10-10 and rs7136702, OR = 1.06, P = 4.02-10 -8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89-10-10). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. {\textcopyright} 2010 Nature America, Inc. All rights reserved.",

author = "Houlston, {Richard S.} and Jeremy Cheadle and Dobbins, {Sara E.} and Albert Tenesa and Jones, {Angela M.} and Kimberley Howarth and Spain, {Sarah L.} and Peter Broderick and Enric Domingo and Susan Farrington and Prendergast, {James G D} and Pittman, {Alan M.} and Evi Theodoratou and Smith, {Christopher G.} and Bianca Olver and Axel Walther and Barnetson, {Rebecca A.} and Michael Churchman and Jaeger, {Emma E M} and Steven Penegar and Ella Barclay and Lynn Martin and Maggie Gorman and Rachel Mager and Elaine Johnstone and Rachel Midgley and Iina Niittym{\"a}ki and Sari Tuupanen and James Colley and Shelley Idziaszczyk and Thomas, {Huw J W} and Lucassen, {Anneke M.} and Evans, {D. Gareth R} and Maher, {Eamonn R.} and Timothy Maughan and Antigone Dimas and Emmanouil Dermitzakis and Cazier, {Jean Baptiste} and Aaltonen, {Lauri A.} and Paul Pharoah and Kerr, {David J.} and Carvajal-Carmona, {Luis G.} and Harry Campbell and Dunlop, {Malcolm G.} and Tomlinson, {Ian P M}",

year = "2010",

month = nov,

doi = "10.1038/ng.670",

language = "English",

volume = "42",

pages = "973--977",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Springer Nature",

number = "11",

}

Houlston, RS, Cheadle, J, Dobbins, SE, Tenesa, A, Jones, AM, Howarth, K, Spain, SL, Broderick, P, Domingo, E, Farrington, S, Prendergast, JGD, Pittman, AM, Theodoratou, E, Smith, CG, Olver, B, Walther, A, Barnetson, RA, Churchman, M, Jaeger, EEM, Penegar, S, Barclay, E, Martin, L, Gorman, M, Mager, R, Johnstone, E, Midgley, R, Niittymäki, I, Tuupanen, S, Colley, J, Idziaszczyk, S, Thomas, HJW, Lucassen, AM, Evans, DGR, Maher, ER, Maughan, T, Dimas, A, Dermitzakis, E, Cazier, JB, Aaltonen, LA, Pharoah, P, Kerr, DJ, Carvajal-Carmona, LG, Campbell, H, Dunlop, MG & Tomlinson, IPM 2010, 'Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33', Nature Genetics, vol. 42, no. 11, pp. 973-977. https://doi.org/10.1038/ng.670

TY - JOUR

T1 - Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

AU - Houlston, Richard S.

AU - Cheadle, Jeremy

AU - Dobbins, Sara E.

AU - Tenesa, Albert

AU - Jones, Angela M.

AU - Howarth, Kimberley

AU - Spain, Sarah L.

AU - Broderick, Peter

AU - Domingo, Enric

AU - Farrington, Susan

AU - Prendergast, James G D

AU - Pittman, Alan M.

AU - Theodoratou, Evi

AU - Smith, Christopher G.

AU - Olver, Bianca

AU - Walther, Axel

AU - Barnetson, Rebecca A.

AU - Churchman, Michael

AU - Jaeger, Emma E M

AU - Penegar, Steven

AU - Barclay, Ella

AU - Martin, Lynn

AU - Gorman, Maggie

AU - Mager, Rachel

AU - Johnstone, Elaine

AU - Midgley, Rachel

AU - Niittymäki, Iina

AU - Tuupanen, Sari

AU - Colley, James

AU - Idziaszczyk, Shelley

AU - Thomas, Huw J W

AU - Lucassen, Anneke M.

AU - Evans, D. Gareth R

AU - Maher, Eamonn R.

AU - Maughan, Timothy

AU - Dimas, Antigone

AU - Dermitzakis, Emmanouil

AU - Cazier, Jean Baptiste

AU - Aaltonen, Lauri A.

AU - Pharoah, Paul

AU - Kerr, David J.

AU - Carvajal-Carmona, Luis G.

AU - Campbell, Harry

AU - Dunlop, Malcolm G.

AU - Tomlinson, Ian P M

PY - 2010/11

Y1 - 2010/11

N2 - Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55-10-10 and rs6687758, OR = 1.09, P = 2.27-10-9), 3q26.2 (rs10936599, OR = 0.93, P = 3.39-10-8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89-10-10 and rs7136702, OR = 1.06, P = 4.02-10 -8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89-10-10). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. © 2010 Nature America, Inc. All rights reserved.

AB - Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55-10-10 and rs6687758, OR = 1.09, P = 2.27-10-9), 3q26.2 (rs10936599, OR = 0.93, P = 3.39-10-8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89-10-10 and rs7136702, OR = 1.06, P = 4.02-10 -8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89-10-10). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. © 2010 Nature America, Inc. All rights reserved.

U2 - 10.1038/ng.670

DO - 10.1038/ng.670

M3 - Article

SN - 1061-4036

VL - 42

SP - 973

EP - 977

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

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