Meta-analysis: Risk of fractures with acid-suppressing medication

Chun Shing Kwok; J. K Y Yeong; Yoon Kong Loke

doi:10.1016/j.bone.2010.12.015

Meta-analysis: Risk of fractures with acid-suppressing medication

Chun Shing Kwok, J. K Y Yeong, Yoon Kong Loke

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: Recent studies have suggested an increased risk of fractures with proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs). We planned to perform a meta-analysis of fractures in patients taking PPIs and H2RAs. Methods: We searched MEDLINE and EMBASE in September 2010 for observational studies reporting on the risk of fractures with acid-suppressing medication (PPIs and H2RA). We also checked the references lists of included studies and regulatory authority websites for additional data. We performed random effects meta-analysis of odds ratios (OR) according to fracture type and conducted subgroup analyses by duration of exposure. Heterogeneity was assessed using the I2 statistic. Results: Our review included 12 studies covering 1,521,062 patients. Pooled analysis of PPI use showed significant risk for spine fractures (4 studies, OR 1.50, 95% CI 1.32-1.72, p

Original language	English
Pages (from-to)	768-776
Number of pages	8
Journal	Bone
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/j.bone.2010.12.015
Publication status	Published - 1 Apr 2011

Keywords

Fractures
Histamine-2 receptor antagonists
Meta-analysis
Proton pump inhibitors

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10.1016/j.bone.2010.12.015

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abstract = "Aims: Recent studies have suggested an increased risk of fractures with proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs). We planned to perform a meta-analysis of fractures in patients taking PPIs and H2RAs. Methods: We searched MEDLINE and EMBASE in September 2010 for observational studies reporting on the risk of fractures with acid-suppressing medication (PPIs and H2RA). We also checked the references lists of included studies and regulatory authority websites for additional data. We performed random effects meta-analysis of odds ratios (OR) according to fracture type and conducted subgroup analyses by duration of exposure. Heterogeneity was assessed using the I2 statistic. Results: Our review included 12 studies covering 1,521,062 patients. Pooled analysis of PPI use showed significant risk for spine fractures (4 studies, OR 1.50, 95% CI 1.32-1.72, p",

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AU - Kwok, Chun Shing

AU - Yeong, J. K Y

AU - Loke, Yoon Kong

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Meta-analysis: Risk of fractures with acid-suppressing medication

Abstract

Keywords

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