Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.

Ubaldo E Martinez-Outschoorn; Federica Sotgia; Michael P Lisanti

doi:10.1016/j.ccr.2014.06.021

Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.

Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti

Research output: Contribution to journal › Article › peer-review

Abstract

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggressive disease with high p62 in anabolic cancer cells, but loss of p62 in catabolic fibroblasts.

Original language	English
Journal	Cancer Cell
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2014.06.021
Publication status	Published - 14 Jul 2014

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10.1016/j.ccr.2014.06.021

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title = "Metabolic asymmetry in cancer: a {"}balancing act{"} that promotes tumor growth.",

abstract = "Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggressive disease with high p62 in anabolic cancer cells, but loss of p62 in catabolic fibroblasts.",

author = "Martinez-Outschoorn, {Ubaldo E} and Federica Sotgia and Lisanti, {Michael P}",

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AB - Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggressive disease with high p62 in anabolic cancer cells, but loss of p62 in catabolic fibroblasts.

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JO - Cancer Cell

JF - Cancer Cell

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Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.

Abstract

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