Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve

L Mosconi, A Pupi, KG Herholz, I Prohovnik, B Nacmias, Cristofaro M T R De, M Fayyaz, L Bracco, S. Sorbi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, viale Morgagni 85, 50134 Florence, Italy.BACKGROUND: Clinically apparent Alzheimer's disease (AD) is thought to result when brain tissue damage exceeds a critical threshold of "brain reserve", a process possibly accelerated by the apolipoprotein E (ApoE) E4 allele. The interaction between onset age and ApoE genotype was investigated to assess whether early disease onset (
    Original languageEnglish
    JournalJournal of Neurology, Neurosurgery and Psychiatry
    Volume76 (1)
    Publication statusPublished - 2005

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