Metabolic Pathway Design: A practical guide

Pablo Carbonell

Research output: Book/ReportBookpeer-review


This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples.
Original languageEnglish
Place of PublicationSwitzerland
PublisherSpringer Nature
Number of pages168
ISBN (Electronic)9783030298654
ISBN (Print)9783030298647
Publication statusPublished - 2019

Publication series

NameLearning materials in Biosciences
PublisherSpringer Nature


  • metabolic engineering
  • synthetic biology

Research Beacons, Institutes and Platforms

  • Manchester Institute of Biotechnology


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