Metabolomics tools for the synthetic biology of natural products

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    Metabolomics plays an increasingly central role in within the Design – Build – Test cycle of synthetic biology, in particular in applications targeting the discovery, diversification and optimized production of a wide range of natural products. For example, improved methods for the online monitoring of chemical reactions accelerate data generation to be compatible with the rapid iterations and increasing library sizes of automated synthetic biology pipelines. Combinations of label-free metabolic profiling and 13C-based flux analysis lead to increased resolution in the identification of metabolic bottlenecks affecting product yield in engineered microbes. And molecular networking strategies drastically increase our ability to identify and characterize novel chemically complex biomolecules of interest in a diverse range of samples.
    Original languageEnglish
    Pages (from-to)114-120
    Number of pages6
    JournalCurrent Opinion in Biotechnology
    Early online date19 Mar 2018
    Publication statusPublished - Dec 2018

    Research Beacons, Institutes and Platforms

    • Manchester Institute of Biotechnology


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