Metal-Free CHCH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group

Jose A. Fernandez-Salas; Andrew J. Eberhart; And David J. Procter

doi:10.1021/jacs.5b12579

Metal-Free CHCH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group

Jose A. Fernandez-Salas
, Andrew J. Eberhart
, And David J. Procter

Research output: Contribution to journal › Article › peer-review

Abstract

A metal-free CH–CH-type coupling of arenes and alkynes, mediated by a multifunctional sulfoxide directing group, exploits nonprefunctionalized coupling partners, proceeds under mild conditions, is operationally simple, and exhibits high functional group tolerance. The products of the CH–CH coupling are highly versatile, and the metal-free process can be used for the construction and late-stage modification of important molecular scaffolds.

Original language	English
Pages (from-to)	790-793
Journal	American Chemical Society. Journal
Volume	138
Issue number	3
DOIs	https://doi.org/10.1021/jacs.5b12579
Publication status	Published - 14 Jan 2016

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title = "Metal-Free CHCH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group",

abstract = "A metal-free CH–CH-type coupling of arenes and alkynes, mediated by a multifunctional sulfoxide directing group, exploits nonprefunctionalized coupling partners, proceeds under mild conditions, is operationally simple, and exhibits high functional group tolerance. The products of the CH–CH coupling are highly versatile, and the metal-free process can be used for the construction and late-stage modification of important molecular scaffolds.",

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AU - Procter, And David J.

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AB - A metal-free CH–CH-type coupling of arenes and alkynes, mediated by a multifunctional sulfoxide directing group, exploits nonprefunctionalized coupling partners, proceeds under mild conditions, is operationally simple, and exhibits high functional group tolerance. The products of the CH–CH coupling are highly versatile, and the metal-free process can be used for the construction and late-stage modification of important molecular scaffolds.

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DO - 10.1021/jacs.5b12579

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JF - American Chemical Society. Journal

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ER -

Metal-Free CHCH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group

Abstract

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