Abstract
A metal-free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides. Substrate scope is very broad under simple, user-friendly conditions, and the reaction can be used to easily access biologically active phenethylamine derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 4183–4186 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 56 |
| Issue number | 15 |
| Early online date | 13 Mar 2017 |
| DOIs | |
| Publication status | Published - 3 Apr 2017 |