Abstract
Data are presented on pharmacodynamic (PD) method validation and preliminary clinical qualification of three PD biomarker assays. M65 Elisa, which quantitates different forms of circulating cytokeratin 18 (CK18) as putative surrogate markers of both apoptotic and nonapoptotic tumour cell death, was shown to be highly reproducible: calibration curve linearity r 2=0.996, mean accuracy >91% and mean precision
Original language | English |
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Pages (from-to) | 42-48 |
Number of pages | 6 |
Journal | British Journal of Cancer |
Volume | 95 |
Issue number | 1 |
DOIs | |
Publication status | Published - 3 Jul 2006 |
Keywords
- Biomarker variability
- M30 Apoptosense
- M65 Elisa
- Quantitative RT-PCR
- Stability
- Validation