Methodological advances enabled by the construction of a synthetic yeast genome

Daniel Schindler; Roy S K Walker; Yizhi Cai

doi:10.1016/j.crmeth.2024.100761

Methodological advances enabled by the construction of a synthetic yeast genome

Daniel Schindler, Roy S K Walker, Yizhi Cai

Chemical Biology and Biological Chemistry

Macquarie University

Research output: Contribution to journal › Article › peer-review

Abstract

The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17thde novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.

Original language	English
Pages (from-to)	100761
Journal	Cell reports methods
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/j.crmeth.2024.100761
Publication status	Published - 22 Apr 2024

Keywords

Genetic Engineering/methods
Genome, Fungal/genetics
Genomics/methods
Saccharomyces cerevisiae/genetics
Synthetic Biology/methods

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10.1016/j.crmeth.2024.100761

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abstract = "The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17thde novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.",

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KW - Genome, Fungal/genetics

KW - Genomics/methods

KW - Saccharomyces cerevisiae/genetics

KW - Synthetic Biology/methods

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Methodological advances enabled by the construction of a synthetic yeast genome

Abstract

Keywords

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