Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1550-1560 |
| Number of pages | 11 |
| Journal | Current Topics in Medicinal Chemistry |
| Volume | 16 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- Airway acidity
- Airway inflammation
- Asthma
- Breath test
- Exhaled breath condensate
- Exhaled breath condensate pH
- biological marker
- buffer
- inert gas
- Article
- asthma
- beverage
- blood carbon dioxide tension
- environmental exposure
- exercise
- exhaled breath condensate pH
- food intake
- forced expiratory volume
- gastroesophageal reflux
- obesity
- pH
- quality of life
- respiratory airflow
- respiratory tract parameters
- smoking
- breath analysis
- human
- metabolism
- Biomarkers
- Breath Tests
- Humans
- Hydrogen-Ion Concentration
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In: Current Topics in Medicinal Chemistry, Vol. 16, No. 14, 2016, p. 1550-1560.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Methodological issues and possible clinical implications for exhaled breath condensate pH in asthma
AU - Bikov, A.
AU - Horvath, I.
N1 - Cited By :4 Export Date: 31 October 2018 CODEN: CTMCC Correspondence Address: Bikova, A.; Department of Pulmonology, Semmelweis University, 1125, Dios arok 1/C, Hungary; email: [email protected] Chemicals/CAS: Biomarkers References: Carraro, S., Doherty, J., Zaman, K., Gainov, I., Turner, R., Vaughan, J., Hunt, J.F., Gaston, B., S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus (2006) Am. J. Physiol. Lung Cell Mol. Physiol., 290 (5), pp. L827-L832; McShane, D., Davies, J.C., Davies, M.G., Bush, A., Geddes, D.M., Alton, E.W., Airway surface pH in subjects with cystic fibrosis (2003) Eur. Respir. J., 21 (1), pp. 37-42; Navarro, M., Pichini, S., Farre, M., Ortuno, J., Roset, P.N., Segura, J., De La Torre, R., Usefulness of saliva for measurement of 3,4-methylenedioxymethamphetamine and its metabolites: Correlation with plasma drug concentrations and effect of salivary pH. 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Allergy, 42 (5), pp. 792-798
PY - 2016
Y1 - 2016
N2 - Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications. © 2016 Bentham Science Publishers.
AB - Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications. © 2016 Bentham Science Publishers.
KW - Airway acidity
KW - Airway inflammation
KW - Asthma
KW - Breath test
KW - Exhaled breath condensate
KW - Exhaled breath condensate pH
KW - biological marker
KW - buffer
KW - inert gas
KW - Article
KW - asthma
KW - beverage
KW - blood carbon dioxide tension
KW - environmental exposure
KW - exercise
KW - exhaled breath condensate pH
KW - food intake
KW - forced expiratory volume
KW - gastroesophageal reflux
KW - obesity
KW - pH
KW - quality of life
KW - respiratory airflow
KW - respiratory tract parameters
KW - smoking
KW - breath analysis
KW - human
KW - metabolism
KW - Biomarkers
KW - Breath Tests
KW - Humans
KW - Hydrogen-Ion Concentration
U2 - 10.2174/1568026616666150930120421
DO - 10.2174/1568026616666150930120421
M3 - Article
SN - 1568-0266
VL - 16
SP - 1550
EP - 1560
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 14
ER -