Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy

Amin Rostami-Hodjegan; Brahim Achour; James E. Rothman

Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy

Amin Rostami-Hodjegan (Inventor), Brahim Achour (Inventor), James E. Rothman (Inventor)

Pharmacy

Yale University

Research output: Patent

Abstract

Methods, systems and apparatus are provided for quantifying the amount of at least a first cell free RNA (cfRNA) present in a liquid biopsy obtained from an individual subject. The first cfRNA may encode a protein that functions in the clearance of xenobiotic compounds from the body of the subject. Quantification of the amount of the first cfRNA is normalised to the individual and permits the construction of more accurate virtual models that facilitate improved personalised medicine, dosage regimens and clinical trials.

Original language	English
Patent number	WO 2019/191297 A1
IPC	C12Q 1/68
Priority date	28/03/18
Filing date	27/03/18
Publication status	Published - 3 Oct 2019

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title = "Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy",

abstract = "Methods, systems and apparatus are provided for quantifying the amount of at least a first cell free RNA (cfRNA) present in a liquid biopsy obtained from an individual subject. The first cfRNA may encode a protein that functions in the clearance of xenobiotic compounds from the body of the subject. Quantification of the amount of the first cfRNA is normalised to the individual and permits the construction of more accurate virtual models that facilitate improved personalised medicine, dosage regimens and clinical trials.",

author = "Amin Rostami-Hodjegan and Brahim Achour and Rothman, {James E.}",

year = "2019",

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language = "English",

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T1 - Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy

AU - Rostami-Hodjegan, Amin

AU - Achour, Brahim

AU - Rothman, James E.

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Methods, systems and apparatus are provided for quantifying the amount of at least a first cell free RNA (cfRNA) present in a liquid biopsy obtained from an individual subject. The first cfRNA may encode a protein that functions in the clearance of xenobiotic compounds from the body of the subject. Quantification of the amount of the first cfRNA is normalised to the individual and permits the construction of more accurate virtual models that facilitate improved personalised medicine, dosage regimens and clinical trials.

AB - Methods, systems and apparatus are provided for quantifying the amount of at least a first cell free RNA (cfRNA) present in a liquid biopsy obtained from an individual subject. The first cfRNA may encode a protein that functions in the clearance of xenobiotic compounds from the body of the subject. Quantification of the amount of the first cfRNA is normalised to the individual and permits the construction of more accurate virtual models that facilitate improved personalised medicine, dosage regimens and clinical trials.

M3 - Patent

M1 - WO 2019/191297 A1

Y2 - 2018/03/27

PB - World Intellectual Property Organization

ER -

Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy

Abstract

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