MHC genes in autoimmunity

Caroline Milner, R. Duncan Campbell

    Research output: Contribution to journalArticlepeer-review


    In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptides that induce autoimmune disease. In addition, the use of animal models and transgenic mouse technology is continuing to increase our understanding of the involvement of the MHC gene products in immunopathogenesis. © Current Biology Ltd.
    Original languageEnglish
    Pages (from-to)887-893
    Number of pages6
    JournalCurrent opinion in immunology
    Issue number6
    Publication statusPublished - 1993


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