Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether

Pablo Taboada; Gemma Velasquez; Silvia Barbosa; Zhuo Yang; S. Keith Nixon; Zhengyuan Zhou; Frank Heatley; Marianne Ashford; Victor Mosquera; David Attwood; Colin Booth

doi:10.1021/la060684+

Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether

Pablo Taboada, Gemma Velasquez, Silvia Barbosa, Zhuo Yang, S. Keith Nixon, Zhengyuan Zhou, Frank Heatley, Marianne Ashford, Victor Mosquera, David Attwood, Colin Booth

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH 2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 °C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene). © 2006 American Chemical Society.

Original language	English
Pages (from-to)	7465-7470
Number of pages	5
Journal	Langmuir
Volume	22
Issue number	18
DOIs	https://doi.org/10.1021/la060684+
Publication status	Published - 29 Aug 2006

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title = "Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether",

abstract = "The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH 2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 °C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene). {\textcopyright} 2006 American Chemical Society.",

author = "Pablo Taboada and Gemma Velasquez and Silvia Barbosa and Zhuo Yang and Nixon, {S. Keith} and Zhengyuan Zhou and Frank Heatley and Marianne Ashford and Victor Mosquera and David Attwood and Colin Booth",

year = "2006",

month = aug,

day = "29",

doi = "10.1021/la060684+",

language = "English",

volume = "22",

pages = "7465--7470",

journal = "Langmuir",

issn = "1520-5827",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether

AU - Taboada, Pablo

AU - Velasquez, Gemma

AU - Barbosa, Silvia

AU - Yang, Zhuo

AU - Nixon, S. Keith

AU - Zhou, Zhengyuan

AU - Heatley, Frank

AU - Ashford, Marianne

AU - Mosquera, Victor

AU - Attwood, David

AU - Booth, Colin

PY - 2006/8/29

Y1 - 2006/8/29

N2 - The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH 2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 °C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene). © 2006 American Chemical Society.

AB - The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH 2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 °C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene). © 2006 American Chemical Society.

U2 - 10.1021/la060684+

DO - 10.1021/la060684+

M3 - Article

SN - 1520-5827

VL - 22

SP - 7465

EP - 7470

JO - Langmuir

JF - Langmuir

IS - 18

ER -

Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether

Abstract

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