Michael-type addition as a tool for surface functionalization

Martin Heggli, Nicola Tirelli, Andreas Zisch, Jeffrey A. Hubbell

    Research output: Contribution to journalArticlepeer-review


    Michael-type addition (conjugate addition reaction between electron-poor olefins and nucleophiles, such as thiols) has been successfully used as a convenient tool for surface functionalization. Due to its mild character, this method is potentially useful for the introduction of sensitive groups, which can provide bioactivity and targeting possibilities to surfaces of, for example, colloidal carriers. As reaction partners, in our study we have used thiols, possibly present in peptidic structures, and acrylates, at the end of protein-repellant PEG chains. Satisfactory results were obtained with thiols in solution and acrylic groups bound to the surface. Alternatively, the use of thiols on the particles, even if generated in situ, did not provide useful results.
    Original languageEnglish
    Pages (from-to)967-973
    Number of pages6
    JournalBioconjugate Chemistry
    Issue number5
    Publication statusPublished - Sept 2003


    Dive into the research topics of 'Michael-type addition as a tool for surface functionalization'. Together they form a unique fingerprint.

    Cite this