Micro-haemodynamics at the maternal fetal interface: experimental, theoretical and clinical perspectives

Qi Zhou, Eleanor Doman, Kerstin Schirrmann, Qi Chen, Ellie Seed, Edward Johnstone, Ravi Selvaganapathy, Anne Juel, Oliver Jensen, Miguel O. Bernabeu, Timm Kruger, Igor Chernyavsky

Research output: Contribution to journalArticlepeer-review


The placenta is a vital interface between the mother and her developing fetus. Micro-haemodynamics of the placenta, where the particulate nature of blood flow cannot be ignored, mediates the relationship between the organ's structure and its function. However, the placenta's complex architecture and its relation to pregnancy pathologies remain poorly understood. This review covers current challenges in characterising placental micro-haemodynamics. Recent progress in three-dimensional multiscale imaging has stimulated development of image-based theoretical models, but existing approaches do not fully harness the available data, and new tools are needed for assimilation of complex imaging datasets. Although the placenta at term is available for in vivo imaging or ex vivo experimentation, insight into placental micro-rheology is limited, necessitating the use of biomimetic models. Micro fluidic approaches offer opportunities for well-controlled characterisation of micro-rheology in complex geometries, but challenges remain in robust fabrication of these systems. Recent advances in high-performance simulations for suspension flows enable parametrisation of key physical processes at the micro-scale. Future progress can be made by optimising computational architecture and integrating micro-haemodynamics with solute transport. Both experimental and computational approaches require translation to the organ scale. New upscaling approaches will need to accommodate non-local interactions in microvascular network flows and address the lack of clear scale-separation across the placental architecture. Together, recent advances in cross-disciplinary imaging and modelling over the last ten years have opened a pathway for an in silico human placenta, accelerating the development of precision obstetrics medicine in the next decade.
Original languageEnglish
Article number100387
JournalCurrent Opinion in Biomedical Engineering
Early online dateJun 2022
Publication statusE-pub ahead of print - Jun 2022


  • Artificial placenta
  • Computer simulations
  • Haemodynamics
  • Human placenta
  • Imaging
  • Microfluidics
  • Upscaling


Dive into the research topics of 'Micro-haemodynamics at the maternal fetal interface: experimental, theoretical and clinical perspectives'. Together they form a unique fingerprint.

Cite this