Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells

J. C G Jeynes; M. J. Bailey; H. Coley; K. J. Kirkby; C. Jeynes

doi:10.1016/j.nimb.2010.02.042

Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells

J. C G Jeynes^*, M. J. Bailey, H. Coley, K. J. Kirkby, C. Jeynes

^*Corresponding author for this work

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Microbeam PIXE was used to analyse platinum in single ovarian cancer cells. Carboplatin sensitive and resistant cells were grown as a monolayer on polypropylene and treated with either carboplatin or cisplatin. Pt from the carboplatin could not be detected. The Pt from cisplatin in the cells could be detected, and significantly more Zn was found in the resistant cells compared to the sensitive cells. The sensitive cells probably accumulated more cisplatin than the resistant ones.

Original language	English
Pages (from-to)	2168-2171
Number of pages	4
Journal	Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume	268
Issue number	11-12
DOIs	https://doi.org/10.1016/j.nimb.2010.02.042
Publication status	Published - Jun 2010

Keywords

Cancer
Carboplatin
Cisplatin
Rutherford Backscattering
Zinc

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nimb.2010.02.042

Cite this

@article{cc99c3d83f00489e91c9a58f52945e3f,

title = "Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells",

abstract = "Microbeam PIXE was used to analyse platinum in single ovarian cancer cells. Carboplatin sensitive and resistant cells were grown as a monolayer on polypropylene and treated with either carboplatin or cisplatin. Pt from the carboplatin could not be detected. The Pt from cisplatin in the cells could be detected, and significantly more Zn was found in the resistant cells compared to the sensitive cells. The sensitive cells probably accumulated more cisplatin than the resistant ones.",

keywords = "Cancer, Carboplatin, Cisplatin, Rutherford Backscattering, Zinc",

author = "Jeynes, \{J. C G\} and Bailey, \{M. J.\} and H. Coley and Kirkby, \{K. J.\} and C. Jeynes",

year = "2010",

month = jun,

doi = "10.1016/j.nimb.2010.02.042",

language = "English",

volume = "268",

pages = "2168--2171",

journal = "Nuclear Instruments \& Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms",

issn = "0168-583X",

publisher = "Elsevier BV",

number = "11-12",

}

TY - JOUR

T1 - Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells

AU - Jeynes, J. C G

AU - Bailey, M. J.

AU - Coley, H.

AU - Kirkby, K. J.

AU - Jeynes, C.

PY - 2010/6

Y1 - 2010/6

N2 - Microbeam PIXE was used to analyse platinum in single ovarian cancer cells. Carboplatin sensitive and resistant cells were grown as a monolayer on polypropylene and treated with either carboplatin or cisplatin. Pt from the carboplatin could not be detected. The Pt from cisplatin in the cells could be detected, and significantly more Zn was found in the resistant cells compared to the sensitive cells. The sensitive cells probably accumulated more cisplatin than the resistant ones.

AB - Microbeam PIXE was used to analyse platinum in single ovarian cancer cells. Carboplatin sensitive and resistant cells were grown as a monolayer on polypropylene and treated with either carboplatin or cisplatin. Pt from the carboplatin could not be detected. The Pt from cisplatin in the cells could be detected, and significantly more Zn was found in the resistant cells compared to the sensitive cells. The sensitive cells probably accumulated more cisplatin than the resistant ones.

KW - Cancer

KW - Carboplatin

KW - Cisplatin

KW - Rutherford Backscattering

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=77953132347&partnerID=8YFLogxK

U2 - 10.1016/j.nimb.2010.02.042

DO - 10.1016/j.nimb.2010.02.042

M3 - Article

AN - SCOPUS:77953132347

SN - 0168-583X

VL - 268

SP - 2168

EP - 2171

JO - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 11-12

ER -

Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this