Microbiology of chronic hyperplastic sinusitis

Katriina Kostamo, Malcolm Richardson, Anni Virolainen-Julkunen, Ilmo Leivo, Henrik Malmberg, Jukka Ylikoski, Elina Toskala

    Research output: Contribution to journalArticlepeer-review


    Background: Patients with chronic hyperplastic sinusitis (CHS) form a heterogeneous group with similar symptoms and similar treatment despite of possible different mechanisms behind the disease. In the present study we focused on the microbiological findings in CHS and compared these results to the patient history in order to find out a possible explanation for the aetiology and chronicity of CHS. Methods: In 30 patients the sinus mucus was collected under endoscopic sinus surgery. Samples from 20 healthy volunteers were collected by nasal lavage. Eosinophil staining, bacterial culturing and fungal staining and culturing were done. Histological samples were obtained from all patients. Results: Bacterial cultures were positive in 93% of the patients compared to 70% in controls. Staphylococcus aureus and coagulase-negative Staphylococci were the two most common findings in both groups. A total of seven patients had positive fungal finding. The only fungal genus found was Aspergillus. In the control group no samples were positive for fungi. Conclusions: Microbiological findings do not seem to explain the chronic course of CHS, but fungi may play some part in the pathophysiology of the disease. These results may be more a reflection of a change in the environment in the paranasal sinuses and a change in normal flora than the actual cause of CHS.
    Original languageEnglish
    Pages (from-to)213-218
    Number of pages5
    Issue number4
    Publication statusPublished - Dec 2004


    • Bacteria
    • Chronic sinusitis
    • Eosinophilia
    • Fungi
    • Polyposis


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