Microdomains for neuron-glia interaction: Parallel fiber signaling to Bergmann glial cells

Jens Grosche, Vitali Matyash, Thomas Möller, Alexej Verkhratsky, Andreas Reichenbach, Helmut Kettenmann

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Astrocytes are considered a reticulate network of cells, through which calcium signals can spread easily. In Bergmann glia, astrocytic cells of the cerebellum, we identified subcellular compartments termed 'glial microdomains'. These elements have a complex surface consisting of thin membrane sheets, contain few mitochondria and wrap around synapses. To test for neuronal interaction with these structures, we electrically stimulated parallel fibers. This stimulation increased intracellular calcium concentration ([Ca2+](i)) in small compartments within Bergmann glial cell processes similar in size to glial microdomains. Thus, a Bergmann glial cell may consist of hundreds of independent compartments capable of autonomous interactions with the particular group of synapses that they ensheath.
    Original languageEnglish
    Pages (from-to)139-143
    Number of pages4
    JournalNature Neuroscience
    Volume2
    Issue number2
    DOIs
    Publication statusPublished - Feb 1999

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