Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Paul Edison; Hilary A. Archer; Alexander Gerhard; Rainer Hinz; Nicola Pavese; Federico E. Turkheimer; Alexander Hammers; Yen Fong Tai; Nick Fox; Angus Kennedy; Martin Rossor; David J. Brooks

doi:10.1016/j.nbd.2008.08.001

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Paul Edison, Hilary A. Archer, Alexander Gerhard, Rainer Hinz, Nicola Pavese, Federico E. Turkheimer, Alexander Hammers, Yen Fong Tai, Nick Fox, Angus Kennedy, Martin Rossor, David J. Brooks

Research output: Contribution to journal › Article › peer-review

Abstract

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11C](R)PK11195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p <0.05) of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p <0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage. © 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	412-419
Number of pages	7
Journal	Neurobiology of disease
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.nbd.2008.08.001
Publication status	Published - Dec 2008

Keywords

Alzheimer
Amyloid
Microglia
PET
PIB
PK11195

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10.1016/j.nbd.2008.08.001

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@article{c0b28aeb6d52497d896ece091930925d,

title = "Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study",

abstract = "[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11C](R)PK11195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p <0.05) of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p <0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

keywords = "Alzheimer, Amyloid, Microglia, PET, PIB, PK11195",

author = "Paul Edison and Archer, {Hilary A.} and Alexander Gerhard and Rainer Hinz and Nicola Pavese and Turkheimer, {Federico E.} and Alexander Hammers and Tai, {Yen Fong} and Nick Fox and Angus Kennedy and Martin Rossor and Brooks, {David J.}",

year = "2008",

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doi = "10.1016/j.nbd.2008.08.001",

language = "English",

volume = "32",

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journal = "Neurobiology of disease",

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T1 - Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

AU - Edison, Paul

AU - Archer, Hilary A.

AU - Gerhard, Alexander

AU - Hinz, Rainer

AU - Pavese, Nicola

AU - Turkheimer, Federico E.

AU - Hammers, Alexander

AU - Tai, Yen Fong

AU - Fox, Nick

AU - Kennedy, Angus

AU - Rossor, Martin

AU - Brooks, David J.

PY - 2008/12

Y1 - 2008/12

N2 - [11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11C](R)PK11195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p <0.05) of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p <0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage. © 2008 Elsevier Inc. All rights reserved.

AB - [11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11C](R)PK11195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p <0.05) of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p <0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage. © 2008 Elsevier Inc. All rights reserved.

KW - Alzheimer

KW - Amyloid

KW - Microglia

KW - PET

KW - PIB

KW - PK11195

U2 - 10.1016/j.nbd.2008.08.001

DO - 10.1016/j.nbd.2008.08.001

M3 - Article

C2 - 18786637

SN - 0969-9961

VL - 32

SP - 412

EP - 419

JO - Neurobiology of disease

JF - Neurobiology of disease

IS - 3

ER -

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Abstract

Keywords

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