Microglial priming as trained immunity in the brain

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In this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that are mobilised after first exposure to an inflammatory stimulus. These mechanisms include long-lasting histone modifications, including H3K4me1 deposition at latent enhancer regions. Although such changes may be beneficial in peripheral infectious disease, in the context of microglial priming they may drive increased microglia reactivity that is damaging in diseases of brain ageing.
Original languageEnglish
Early online date29 Dec 2017
Publication statusPublished - 2018

Research Beacons, Institutes and Platforms

  • Manchester Institute for Collaborative Research on Ageing


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