Microglial priming as trained immunity in the brain

Michael Haley; David Brough; Jessica Quintin; Stuart Allan

doi:10.1016/j.neuroscience.2017.12.039

Microglial priming as trained immunity in the brain

Michael Haley, David Brough, Jessica Quintin, Stuart Allan

Division of Neuroscience

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Abstract

In this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that are mobilised after first exposure to an inflammatory stimulus. These mechanisms include long-lasting histone modifications, including H3K4me1 deposition at latent enhancer regions. Although such changes may be beneficial in peripheral infectious disease, in the context of microglial priming they may drive increased microglia reactivity that is damaging in diseases of brain ageing.

Original language	English
Journal	Neuroscience
Early online date	29 Dec 2017
DOIs	https://doi.org/10.1016/j.neuroscience.2017.12.039
Publication status	Published - 2018

Research Beacons, Institutes and Platforms

Manchester Institute for Collaborative Research on Ageing

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10.1016/j.neuroscience.2017.12.039

Haley et al_NeuroscienceAccepted author manuscript, 137 KB

Contribution of Neuro-inflammation to cerebral ischaemia
Brough, D. (PI), Allan, S. (CoI), Kostarelos, K. (CoI) & Rothwell, N. (CoI)
31/12/15 → 30/06/19
Project: Research

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title = "Microglial priming as trained immunity in the brain",

abstract = "In this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that are mobilised after first exposure to an inflammatory stimulus. These mechanisms include long-lasting histone modifications, including H3K4me1 deposition at latent enhancer regions. Although such changes may be beneficial in peripheral infectious disease, in the context of microglial priming they may drive increased microglia reactivity that is damaging in diseases of brain ageing.",

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AB - In this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that are mobilised after first exposure to an inflammatory stimulus. These mechanisms include long-lasting histone modifications, including H3K4me1 deposition at latent enhancer regions. Although such changes may be beneficial in peripheral infectious disease, in the context of microglial priming they may drive increased microglia reactivity that is damaging in diseases of brain ageing.

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Microglial priming as trained immunity in the brain

Abstract

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Contribution of Neuro-inflammation to cerebral ischaemia

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