Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Nugroho; Nicholas Stafford; Min Zi; Sukhpal Prehar; Ryan Potter; Dowan  Kwon; Yulia Kohar; Efta Triastuti; Thuy Anh Bu

Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Nugroho, Nicholas Stafford, Min Zi, Sukhpal Prehar, Ryan Potter, Dowan Kwon, Yulia Kohar, Efta Triastuti, Thuy Anh Bu

Research output: Contribution to journal › Article › peer-review

Abstract

Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged
hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during
embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified
miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly
increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity
of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces
cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP
pathway.

Original language	English
Journal	JACC: Basic to Translational Science
Publication status	Published - 2022

Targeting the Hippo Pathway to Enhance the Regenerative Capacity of IPS-Derived Cardiomyocyte.
Oceandy, D. (PI) & Cartwright, E. (CoI)
1/04/18 → 31/03/21
Project: Research
The Role of Plasma Membrane Calcium ATPase 4 (PMCA4) in Modulating Plasmodium Infection and Malaria Severity.
Oceandy, D. (PI) & Couper, K. (CoI)
1/10/17 → 31/07/20
Project: Research

Cite this

@article{5f6cd60bded7452da08187df65c831f1,

title = "Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice",

abstract = "Induction of endogenous regenerative capacity has emerged as one promising approach to repair damagedhearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed duringembryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identifiedmiR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantlyincreased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activityof YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 inducescardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAPpathway.",

author = "Ardiansah Nugroho and Nicholas Stafford and Min Zi and Sukhpal Prehar and Ryan Potter and Dowan Kwon and Yulia Kohar and Efta Triastuti and {Anh Bu}, Thuy",

year = "2022",

language = "English",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

AU - Nugroho, Ardiansah

AU - Stafford, Nicholas

AU - Zi, Min

AU - Prehar, Sukhpal

AU - Potter, Ryan

AU - Kwon, Dowan

AU - Kohar, Yulia

AU - Triastuti, Efta

AU - Anh Bu, Thuy

PY - 2022

Y1 - 2022

N2 - Induction of endogenous regenerative capacity has emerged as one promising approach to repair damagedhearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed duringembryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identifiedmiR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantlyincreased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activityof YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 inducescardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAPpathway.

AB - Induction of endogenous regenerative capacity has emerged as one promising approach to repair damagedhearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed duringembryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identifiedmiR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantlyincreased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activityof YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 inducescardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAPpathway.

M3 - Article

SN - 2452-302X

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

ER -

Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Abstract

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Projects

Targeting the Hippo Pathway to Enhance the Regenerative Capacity of IPS-Derived Cardiomyocyte.

The Role of Plasma Membrane Calcium ATPase 4 (PMCA4) in Modulating Plasmodium Infection and Malaria Severity.

Cite this