Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Nugroho, Nicholas Stafford, Min Zi, Sukhpal Prehar, Ryan Potter, Dowan Kwon, Yulia Kohar, Efta Triastuti, Thuy Anh Bu

Research output: Contribution to journalArticlepeer-review


Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged
hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during
embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified
miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly
increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity
of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces
cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP
Original languageEnglish
JournalJACC: Basic to Translational Science
Publication statusPublished - 2022


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