Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Nugroho; Nicholas Stafford; Min Zi; Sukhpal Prehar; Ryan Potter; Dowan  Kwon; Yulia Kohar; Efta Triastuti; Thuy Anh Bu; Elizabeth Cartwright; Delvac Oceandy

doi:10.1016/j.jacbts.2022.05.008

Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Ardiansah Nugroho
, Nicholas Stafford
, Min Zi
, Sukhpal Prehar
, Ryan Potter
, Dowan Kwon
, Yulia Kohar
, Efta Triastuti
, Thuy Anh Bu
, Elizabeth Cartwright
, Delvac Oceandy

Research output: Contribution to journal › Article › peer-review

Abstract

Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

Original language	English
Pages (from-to)	859-875
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	7
Issue number	9
Early online date	17 Aug 2022
DOIs	https://doi.org/10.1016/j.jacbts.2022.05.008
Publication status	Published - 1 Sept 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cardiac remodeling
heart failure
Hippo pathway
microRNA-411
myocardial infarction

Access to Document

10.1016/j.jacbts.2022.05.008Licence: CC BY

Targeting the Hippo Pathway to Enhance the Regenerative Capacity of IPS-Derived Cardiomyocyte.
Oceandy, D. (PI) & Cartwright, E. (CoI)
1/04/18 → 31/03/21
Project: Research
The Role of Plasma Membrane Calcium ATPase 4 (PMCA4) in Modulating Plasmodium Infection and Malaria Severity.
Oceandy, D. (PI) & Couper, K. (CoI)
1/10/17 → 31/07/20
Project: Research

Cite this

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title = "Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice",

abstract = "Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.",

keywords = "cardiac remodeling, heart failure, Hippo pathway, microRNA-411, myocardial infarction",

author = "Ardiansah Nugroho and Nicholas Stafford and Min Zi and Sukhpal Prehar and Ryan Potter and Dowan Kwon and Yulia Kohar and Efta Triastuti and \{Anh Bu\}, Thuy and Elizabeth Cartwright and Delvac Oceandy",

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doi = "10.1016/j.jacbts.2022.05.008",

language = "English",

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}

TY - JOUR

T1 - Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

AU - Nugroho, Ardiansah

AU - Stafford, Nicholas

AU - Zi, Min

AU - Prehar, Sukhpal

AU - Potter, Ryan

AU - Kwon, Dowan

AU - Kohar, Yulia

AU - Triastuti, Efta

AU - Anh Bu, Thuy

AU - Cartwright, Elizabeth

AU - Oceandy, Delvac

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

AB - Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

KW - cardiac remodeling

KW - heart failure

KW - Hippo pathway

KW - microRNA-411

KW - myocardial infarction

U2 - 10.1016/j.jacbts.2022.05.008

DO - 10.1016/j.jacbts.2022.05.008

M3 - Article

C2 - 36317138

SN - 2452-302X

VL - 7

SP - 859

EP - 875

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 9

ER -

Microrna-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Abstract

UN SDGs

Keywords

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Projects

Targeting the Hippo Pathway to Enhance the Regenerative Capacity of IPS-Derived Cardiomyocyte.

The Role of Plasma Membrane Calcium ATPase 4 (PMCA4) in Modulating Plasmodium Infection and Malaria Severity.

Cite this