Microtubule regulation: transcending the tenet of K40 acetylation

Andreas Prokop

doi:10.1016/j.cub.2021.12.018

Microtubule regulation: transcending the tenet of K40 acetylation

Andreas Prokop

Division of Molecular & Cellular Function (L5)

Research output: Contribution to journal › Article

Abstract

Summary For 36 years, the acetylation of lysine 40 in α-tubulin has provided the paradigm for how post-translational acetylation stabilises microtubules. A new study demonstrates that acetylation of lysine 394 in α-tubulin also mediates microtubule stabilisation in neurons.

Original language	English
Pages (from-to)	R126-8
Journal	Curr Biol
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.cub.2021.12.018
Publication status	Published - 7 Feb 2022

Keywords

microtubules
Posttranslational modifications
acetylation
tubulin
Drosophila
neuromuscular junction
Stabilisation

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title = "Microtubule regulation: transcending the tenet of K40 acetylation",

abstract = "Summary For 36 years, the acetylation of lysine 40 in α-tubulin has provided the paradigm for how post-translational acetylation stabilises microtubules. A new study demonstrates that acetylation of lysine 394 in α-tubulin also mediates microtubule stabilisation in neurons.",

keywords = "microtubules, Posttranslational modifications, acetylation, tubulin, Drosophila, neuromuscular junction, Stabilisation",

author = "Andreas Prokop",

year = "2022",

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day = "7",

doi = "10.1016/j.cub.2021.12.018",

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AU - Prokop, Andreas

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AB - Summary For 36 years, the acetylation of lysine 40 in α-tubulin has provided the paradigm for how post-translational acetylation stabilises microtubules. A new study demonstrates that acetylation of lysine 394 in α-tubulin also mediates microtubule stabilisation in neurons.

KW - microtubules

KW - Posttranslational modifications

KW - acetylation

KW - tubulin

KW - Drosophila

KW - neuromuscular junction

KW - Stabilisation

U2 - 10.1016/j.cub.2021.12.018

DO - 10.1016/j.cub.2021.12.018

M3 - Article

SN - 0960-9822

VL - 32

SP - R126-8

JO - Curr Biol

JF - Curr Biol

IS - 3

ER -

Microtubule regulation: transcending the tenet of K40 acetylation

Abstract

Keywords

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