Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression.

Anna Caroli, Annapaola Prestia, Samantha Galluzzi, Clarissa Ferrari, Wiesje M van der Flier, Rik Ossenkoppele, Bart Van Berckel, Frederik Barkhof, Charlotte Teunissen, Anders E Wall, Stephen F Carter, Michael Schöll, Il Han Choo, Timo Grimmer, Alberto Redolfi, Agneta Nordberg, Philip Scheltens, Alexander Drzezga, Giovanni B Frisoni, Michael Weiner (Collaborator)Paul Aisen (Collaborator), Ronald Petersen (Collaborator), Clifford R Jack (Collaborator), William Jagust (Collaborator), J Q Trojanowki (Collaborator), Arthur W Toga (Collaborator), Laurel Beckett (Collaborator), Robert C Green (Collaborator), Anthony Gamst (Collaborator), Andrew J Saykin (Collaborator), John Morris (Collaborator), William Z Potter (Collaborator), Tom Montine (Collaborator), Ronald G Thomas (Collaborator), Michael Donohue (Collaborator), Sarah Walter (Collaborator), Anders Dale (Collaborator), Matthew Bernstein (Collaborator), Joel Felmlee (Collaborator), Nick Fox (Collaborator), Paul Thompson (Collaborator), Norbert Schuff (Collaborator), Gene Alexander (Collaborator), Charles DeCarli (Collaborator), Dan Bandy (Collaborator), Robert A Koeppe (Collaborator), Norm Foster (Collaborator), Eric M Reiman (Collaborator), Kewei Chen (Collaborator), Chet Mathis (Collaborator), Nigel J Cairns (Collaborator), Lisa Taylor-Reinwald (Collaborator), Les Shaw (Collaborator), Virginia M-Y Lee (Collaborator), Magdalena Korecka (Collaborator), Karen Crawford (Collaborator), Scott Neu (Collaborator), Danielle Harvey (Collaborator), John Kornak (Collaborator), Tatiana M Foroud (Collaborator), Steven Potkin (Collaborator), Li Shen (Collaborator), Zaven Kachaturian (Collaborator), Richard Frank (Collaborator), Peter J Snyder (Collaborator), Susan Molchan (Collaborator), Jeffrey Kaye (Collaborator), Sara Dolen (Collaborator), Joseph Quinn (Collaborator), Lon Schneider (Collaborator), Sonia Pawluczyk (Collaborator), Bryan M Spann (Collaborator), James Brewer (Collaborator), Helen Vanderswag (Collaborator), Judith L Heidebrink (Collaborator), Joanne L Lord (Collaborator), Kris Johnson (Collaborator), Rachelle S Doody (Collaborator), Javier Villanueva-Meyer (Collaborator), Munir Chowdhury (Collaborator), Yaakov Stern (Collaborator), Lawrence S Honig (Collaborator), Karen L Bell (Collaborator), John C Morris (Collaborator), Mark A Mintun (Collaborator), Stacy Schneider (Collaborator), Daniel Marson (Collaborator), Randall Griffith (Collaborator), David Clark (Collaborator), Hillel Grossman (Collaborator), Cheuk Tang (Collaborator), George Marzloff (Collaborator), Leyla deToledo-Morrell (Collaborator), Raj C Shah (Collaborator), Ranjan Duara (Collaborator), Daniel Varon (Collaborator), Peggy Roberts (Collaborator), Marilyn S Albert (Collaborator), Nicholas Kozauer (Collaborator), Maria Zerrate (Collaborator), Henry Rusinek (Collaborator), Mony J de Leon (Collaborator), Susan M De Santi (Collaborator), P Murali Doraiswamy (Collaborator), Jeffrey R Petrella (Collaborator), Marilyn Aiello (Collaborator), Steve Arnold (Collaborator), Jason H Karlawish (Collaborator), David Wolk (Collaborator), Charles D Smith (Collaborator), Curtis A Given (Collaborator), Peter Hardy (Collaborator), Oscar L Lopez (Collaborator), MaryAnn Oakley (Collaborator), Donna M Simpson (Collaborator), M Saleem Ismail (Collaborator), Connie Brand (Collaborator), Jennifer Richard (Collaborator), Ruth A Mulnard (Collaborator), Gaby Thai (Collaborator), Catherine Mc-Adams-Ortiz (Collaborator), Ramon Diaz-Arrastia (Collaborator), Kristen Martin-Cook (Collaborator), Michael DeVous (Collaborator), Allan I Levey (Collaborator), James J Lah (Collaborator), Janet S Cellar (Collaborator), Jeffrey M Burns (Collaborator), Heather S Anderson (Collaborator), Mary M Laubinger (Collaborator), Liana Apostolova (Collaborator), Daniel H S Silverman (Collaborator), Po H Lu (Collaborator), Neill R Graff-Radford (Collaborator), Francine Parfitt (Collaborator), Heather Johnson (Collaborator), Martin Farlow (Collaborator), Scott Herring (Collaborator), Ann M Hake (Collaborator), Christopher H van Dyck (Collaborator), Martha G MacAvoy (Collaborator), Amanda L Benincasa (Collaborator), Howard Chertkow (Collaborator), Howard Bergman (Collaborator), Chris Hosein (Collaborator), Sandra Black (Collaborator), Bojana Stefanovic (Collaborator), Curtis Caldwell (Collaborator), Ging-Yuek Robin Hsiung (Collaborator), Howard Feldman (Collaborator), Michele Assaly (Collaborator), Andrew Kertesz (Collaborator), John Rogers (Collaborator), Dick Trost (Collaborator), Charles Bernick (Collaborator), Donna Munic (Collaborator), Chuang-Kuo Wu (Collaborator), Nancy Johnson (Collaborator), Marsel Mesulam (Collaborator), Carl Sadowsky (Collaborator), Walter Martinez (Collaborator), Teresa Villena (Collaborator), Raymond Scott Turner (Collaborator), Kathleen Johnson (Collaborator), Brigid Reynolds (Collaborator), Reisa A Sperling (Collaborator), Dorene M Rentz (Collaborator), Keith A Johnson (Collaborator), Allyson Rosen (Collaborator), Jared Tinklenberg (Collaborator), Wes Ashford (Collaborator), Marwan Sabbagh (Collaborator), Donald Connor (Collaborator), Sandra Jacobson (Collaborator), Ronald Killiany (Collaborator), Alexander Norbash (Collaborator), Anil Nair (Collaborator), Thomas O Obisesan (Collaborator), Annapurni Jayam-Trouth (Collaborator), Paul Wang (Collaborator), Alan Lerner (Collaborator), Leon Hudson (Collaborator), Paula Ogrocki (Collaborator), Evan Fletcher (Collaborator), Owen Carmichael (Collaborator), Smita Kittur (Collaborator), Michael Borrie (Collaborator), T-Y Lee (Collaborator), Rob Bartha (Collaborator), Sterling Johnson (Collaborator), Sanjay Asthana (Collaborator), Cynthia M Carlsson (Collaborator), Steven G Potkin (Collaborator), Adrian Preda (Collaborator), Dana Nguyen (Collaborator), Pierre Tariot (Collaborator), Adam Fleisher (Collaborator), Stephanie Reeder (Collaborator), Vernice Bates (Collaborator), Horacio Capote (Collaborator), Michelle Rainka (Collaborator), Barry A Hendin (Collaborator), Douglas W Scharre (Collaborator), Maria Kataki (Collaborator), Earl A Zimmerman (Collaborator), Dzintra Celmins (Collaborator), Alice D Brown (Collaborator), Godfrey Pearlson (Collaborator), Karen Blank (Collaborator), Karen Anderson (Collaborator), Robert B Santulli (Collaborator), Jessica Englert (Collaborator), Jeff D Williamson (Collaborator), Kaycee M Sink (Collaborator), Franklin Watkins (Collaborator), Brian R Ott (Collaborator), Edward Stopa (Collaborator), Geoffrey Tremont (Collaborator), Stephen Salloway (Collaborator), Paul Malloy (Collaborator), Stephen Correia (Collaborator), Howard J Rosen (Collaborator), Bruce L Miller (Collaborator), Jacobo Mintzer (Collaborator), Crystal Flynn Longmire (Collaborator), Kenneth Spicer (Collaborator)

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVES: The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI). METHODS: We measured markers of amyloid pathology (CSF β-amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [(18)F]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases. RESULTS: The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE ε4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p ≤ 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p <0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073). CONCLUSIONS: Our findings support the notion that patients with SNAP MCI feature a specific risk progression profile.
    Original languageEnglish
    JournalNeurology
    Volume84
    Issue number5
    DOIs
    Publication statusPublished - 3 Feb 2015

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