Abstract
MiRBase is the primary online repository for all microRNA sequences and annotation. The current release (miRBase 16) contains over 15 000 microRNA gene loci in over 140 species, and over 17 000 distinct mature microRNA sequences. Deepsequencing technologies have delivered a sharp rise in the rate of novel microRNA discovery. We have mapped reads from short RNA deep-sequencing experiments to microRNAs in miRBase and developed web interfaces to view these mappings. The user can view all read data associated with a given microRNA annotation, filter reads by experiment and count, and search for microRNAs by tissueand stage-specific expression. These data can be used as a proxy for relative expression levels of microRNA sequences, provide detailed evidence for microRNA annotations and alternative isoforms of mature microRNAs, and allow us to revisit previous annotations. miRBase is available online at: http://www.mirbase.org/. © The Author(s) 2010.
| Original language | English |
|---|---|
| Pages (from-to) | D152-D157 |
| Journal | Nucleic acids research. |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
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Dive into the research topics of 'MiRBase: Integrating microRNA annotation and deep-sequencing data'. Together they form a unique fingerprint.Impacts
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The miRBase database – an essential resource for tool development and pharmaceutical research
Sam Griffiths-Jones (Participant), Antonio Marco Castillo (Participant) & Ana Kozomara (Participant)
Impact: Health impacts, Technological impacts, Economic impacts
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The miRBase microRNA database – driving the development of commercial microRNA research tools, diagnostics and therapeutics
Sam Griffiths-Jones (Participant), Ana Kozomara (Participant) & Maria Birgaoanu (Participant)
Impact: Technological impacts, Economic, Health and wellbeing, Policy