miRBase: Tools for microRNA genomics

Sam Griffiths-Jones; Harpreet Kaur Saini; Stijn Van Dongen; Anton J. Enright

doi:10.1093/nar/gkm952

miRBase: Tools for microRNA genomics

Sam Griffiths-Jones, Harpreet Kaur Saini, Stijn Van Dongen, Anton J. Enright

Research output: Contribution to journal › Article › peer-review

Abstract

miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature miRNA sequences: a growth of over 2000 sequences in the past 2 years. miRBase provides a range of data to facilitate studies of miRNA genomics: all miRNAs are mapped to their genomic coordinates. Clusters of miRNA sequences in the genome are highlighted, and can be defined and retrieved with any inter-miRNA distance. The overlap of miRNA sequences with annotated transcripts, both protein- and non-coding, are described. Finally, graphical views of the locations of a wide range of genomic features in model organisms allow for the first time the prediction of the likely boundaries of many miRNA primary transcripts. miRBase is available at http://microrna.sanger.ac.uk/. © 2007 The Author(s).

Original language	English
Pages (from-to)	D154-D158
Journal	Nucleic acids research.
Volume	36
Issue number	1
DOIs	https://doi.org/10.1093/nar/gkm952
Publication status	Published - Jan 2008

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10.1093/nar/gkm952

The miRBase database – an essential resource for tool development and pharmaceutical research
Griffiths-Jones, S. (Participant), (Participant) & (Participant)
Impact: Health impacts, Technological impacts, Economic impacts

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title = "miRBase: Tools for microRNA genomics",

abstract = "miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature miRNA sequences: a growth of over 2000 sequences in the past 2 years. miRBase provides a range of data to facilitate studies of miRNA genomics: all miRNAs are mapped to their genomic coordinates. Clusters of miRNA sequences in the genome are highlighted, and can be defined and retrieved with any inter-miRNA distance. The overlap of miRNA sequences with annotated transcripts, both protein- and non-coding, are described. Finally, graphical views of the locations of a wide range of genomic features in model organisms allow for the first time the prediction of the likely boundaries of many miRNA primary transcripts. miRBase is available at http://microrna.sanger.ac.uk/. {\textcopyright} 2007 The Author(s).",

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miRBase: Tools for microRNA genomics

Abstract

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The miRBase database – an essential resource for tool development and pharmaceutical research

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