Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen

Gina L J Galli, Jeffrey G. Richards

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The mitochondrion plays a critical role in the development of Oxygen (O2)-related diseases. While research has predominantly focused on hypoxia-sensitive mammals as surrogates for humans, the use of animals which have naturally evolved anoxia tolerance has been largely ignored. Remarkably, some animals can live in the complete absence of O2 for days, months and even years, but surprisingly little is currently known about mitochondrial function in these species. In contrast to mammals, mitochondrial function in anoxia-tolerant animals is relatively insensitive to in vitro anoxia and reoxygenation, suggesting that anoxia tolerance transcends to the level of the mitochondria. Furthermore, long-term anoxia is associated with marked changes in the intrinsic properties of the mitochondria from these species, which may afford protection against anoxia-related damage. In the present review, we highlight some of the strategies anoxia-tolerant animals possess to preserve mitochondrial function in the absence of O2. Specifically, we review mitochondrial Ca2+ regulation, proton leak, redox signaling and mitochondrial permeability transition, in phylogenetically diverse groups of anoxia-tolerant animals. From the strategies they employ, these species emerge as model organisms to illuminate novel interventions to mitigate O2-related mitochondrial dysfunction in humans. © 2014 Springer-Verlag Berlin Heidelberg.
    Original languageEnglish
    Pages (from-to)285-302
    Number of pages17
    JournalJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
    Volume184
    Issue number3
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Anoxia
    • Ectothermic
    • Electron transport chain
    • Mitochondria
    • Mitochondrial permeability transition pore
    • Proton leak

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