TY - JOUR
T1 - Mitochondrial complex I and cell death: A semi-automatic shotgun model
AU - Degli Esposti, Mauro
AU - Gonzalez-Halphen, D.
AU - Ghelli, A.
AU - Iommarini, L.
AU - Carelli, V.
AU - Esposti, M. D.
PY - 2011/10
Y1 - 2011/10
N2 - Mitochondrial dysfunction often leads to cell death and disease.We can now draw correlations between the dysfunction of one of the most important mitochondrial enzymes, NADH:ubiquinone reductase or complex I, and its structural organization thanks to the recent advances in the X-ray structure of its bacterial homologs. The new structural information on bacterial complex I provide essential clues to finally understand how complex I may work. However, the same information remains difficult to interpret for many scientists working on mitochondrial complex I from different angles, especially in the field of cell death. Here, we present a novel way of interpreting the bacterial structural information in accessible terms. On the basis of the analogy to semi-automatic shotguns, we propose a novel functional model that incorporates recent structural information with previous evidence derived from studies on mitochondrial diseases, as well as functional bioenergetics. © 2011 Macmillan Publishers Limited.
AB - Mitochondrial dysfunction often leads to cell death and disease.We can now draw correlations between the dysfunction of one of the most important mitochondrial enzymes, NADH:ubiquinone reductase or complex I, and its structural organization thanks to the recent advances in the X-ray structure of its bacterial homologs. The new structural information on bacterial complex I provide essential clues to finally understand how complex I may work. However, the same information remains difficult to interpret for many scientists working on mitochondrial complex I from different angles, especially in the field of cell death. Here, we present a novel way of interpreting the bacterial structural information in accessible terms. On the basis of the analogy to semi-automatic shotguns, we propose a novel functional model that incorporates recent structural information with previous evidence derived from studies on mitochondrial diseases, as well as functional bioenergetics. © 2011 Macmillan Publishers Limited.
KW - Complex I
KW - Mitochondria
KW - Mitochondrial disease
U2 - 10.1038/cddis.2011.107
DO - 10.1038/cddis.2011.107
M3 - Article
C2 - 22030538
SN - 2041-4889
VL - 2
JO - Cell Death and Disease
JF - Cell Death and Disease
IS - 10
M1 - e222
ER -