Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

A. Strakova; M.N. Leathlobhair; G.-D. Wang; T.-T. Yin; I. Airikkala-Otter; J.L. Allen; K.M. Allum; L. Bansse-Issa; J.L. Bisson; A.C. Domracheva; K.F. De Castro; A.M. Corrigan; H.R. Cran; J.T. Crawford; S.M. Cutter; L.D. Keenan; E.M. Donelan; I.A. Faramade; E.F. Reynoso; E. Fotopoulou; S.N. Fruean; F. Gallardo-Arrieta; O. Glebova; R.F. Häfelin Manrique; J.J.G.P. Henriques; N. Ignatenko; D. Koenig; M. Lanza-Perea; R. Lobetti; A.M. Lopezquintana; T. Losfelt; G. Marino; I. Martincorena; S.M. Castañeda; M.F. Martínez-López; M. Meyer; B. Nakanwagi; A.B. De Nardi; W. Neunzig; S.J. Nixon; M.M. Onsare; A. Ortega-Pacheco; M.C. Peleteiro; R.J. Pye; J.F. Reece; J.R. Gutierrez; H. Sadia; S.K. Schmeling; O. Shamanova; R.K. Ssuna; A.E. Steenland-Smitsvitich; I.T. Ngoka; B.A. Vitǎlaru; A.P. De Vos; J.P. De Vos; O. Walkinton; D.C. Wedge; A.S. Wehrle-Martinez; M.G. Van Der Wel; S.A. Widdowson; E.P. Murchison

doi:10.7554/eLife.14552

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

A. Strakova, M.N. Leathlobhair, G.-D. Wang, T.-T. Yin, I. Airikkala-Otter, J.L. Allen, K.M. Allum, L. Bansse-Issa, J.L. Bisson, A.C. Domracheva, K.F. De Castro, A.M. Corrigan, H.R. Cran, J.T. Crawford, S.M. Cutter, L.D. Keenan, E.M. Donelan, I.A. Faramade, E.F. Reynoso, E. FotopoulouS.N. Fruean, F. Gallardo-Arrieta, O. Glebova, R.F. Häfelin Manrique, J.J.G.P. Henriques, N. Ignatenko, D. Koenig, M. Lanza-Perea, R. Lobetti, A.M. Lopezquintana, T. Losfelt, G. Marino, I. Martincorena, S.M. Castañeda, M.F. Martínez-López, M. Meyer, B. Nakanwagi, A.B. De Nardi, W. Neunzig, S.J. Nixon, M.M. Onsare, A. Ortega-Pacheco, M.C. Peleteiro, R.J. Pye, J.F. Reece, J.R. Gutierrez, H. Sadia, S.K. Schmeling, O. Shamanova, R.K. Ssuna, A.E. Steenland-Smitsvitich, I.T. Ngoka, B.A. Vitǎlaru, A.P. De Vos, J.P. De Vos, O. Walkinton, D.C. Wedge, A.S. Wehrle-Martinez, M.G. Van Der Wel, S.A. Widdowson, E.P. Murchison

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

Original language	English
Journal	eLife
Volume	5
DOIs	https://doi.org/10.7554/eLife.14552
Publication status	Published - 17 May 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7554/eLife.14552Licence: CC BY

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Strakova, A., Leathlobhair, M. N., Wang, G.-D., Yin, T.-T., Airikkala-Otter, I., Allen, J. L., Allum, K. M., Bansse-Issa, L., Bisson, J. L., Domracheva, A. C., De Castro, K. F., Corrigan, A. M., Cran, H. R., Crawford, J. T., Cutter, S. M., Keenan, L. D., Donelan, E. M., Faramade, I. A., Reynoso, E. F., ... Murchison, E. P. (2016). Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer. eLife, 5. https://doi.org/10.7554/eLife.14552

@article{835305fd59664583aee2d88f79ce0b52,

title = "Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer",

abstract = "Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.",

author = "A. Strakova and M.N. Leathlobhair and G.-D. Wang and T.-T. Yin and I. Airikkala-Otter and J.L. Allen and K.M. Allum and L. Bansse-Issa and J.L. Bisson and A.C. Domracheva and {De Castro}, K.F. and A.M. Corrigan and H.R. Cran and J.T. Crawford and S.M. Cutter and L.D. Keenan and E.M. Donelan and I.A. Faramade and E.F. Reynoso and E. Fotopoulou and S.N. Fruean and F. Gallardo-Arrieta and O. Glebova and {H{\"a}felin Manrique}, R.F. and J.J.G.P. Henriques and N. Ignatenko and D. Koenig and M. Lanza-Perea and R. Lobetti and A.M. Lopezquintana and T. Losfelt and G. Marino and I. Martincorena and S.M. Casta{\~n}eda and M.F. Mart{\'i}nez-L{\'o}pez and M. Meyer and B. Nakanwagi and {De Nardi}, A.B. and W. Neunzig and S.J. Nixon and M.M. Onsare and A. Ortega-Pacheco and M.C. Peleteiro and R.J. Pye and J.F. Reece and J.R. Gutierrez and H. Sadia and S.K. Schmeling and O. Shamanova and R.K. Ssuna and A.E. Steenland-Smitsvitich and I.T. Ngoka and B.A. Vitǎlaru and {De Vos}, A.P. and {De Vos}, J.P. and O. Walkinton and D.C. Wedge and A.S. Wehrle-Martinez and {Van Der Wel}, M.G. and S.A. Widdowson and E.P. Murchison",

year = "2016",

month = may,

day = "17",

doi = "10.7554/eLife.14552",

language = "English",

volume = "5",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications",

}

Strakova, A, Leathlobhair, MN, Wang, G-D, Yin, T-T, Airikkala-Otter, I, Allen, JL, Allum, KM, Bansse-Issa, L, Bisson, JL, Domracheva, AC, De Castro, KF, Corrigan, AM, Cran, HR, Crawford, JT, Cutter, SM, Keenan, LD, Donelan, EM, Faramade, IA, Reynoso, EF, Fotopoulou, E, Fruean, SN, Gallardo-Arrieta, F, Glebova, O, Häfelin Manrique, RF, Henriques, JJGP, Ignatenko, N, Koenig, D, Lanza-Perea, M, Lobetti, R, Lopezquintana, AM, Losfelt, T, Marino, G, Martincorena, I, Castañeda, SM, Martínez-López, MF, Meyer, M, Nakanwagi, B, De Nardi, AB, Neunzig, W, Nixon, SJ, Onsare, MM, Ortega-Pacheco, A, Peleteiro, MC, Pye, RJ, Reece, JF, Gutierrez, JR, Sadia, H, Schmeling, SK, Shamanova, O, Ssuna, RK, Steenland-Smitsvitich, AE, Ngoka, IT, Vitǎlaru, BA, De Vos, AP, De Vos, JP, Walkinton, O, Wedge, DC, Wehrle-Martinez, AS, Van Der Wel, MG, Widdowson, SA & Murchison, EP 2016, 'Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer', eLife, vol. 5. https://doi.org/10.7554/eLife.14552

TY - JOUR

T1 - Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

AU - Strakova, A.

AU - Leathlobhair, M.N.

AU - Wang, G.-D.

AU - Yin, T.-T.

AU - Airikkala-Otter, I.

AU - Allen, J.L.

AU - Allum, K.M.

AU - Bansse-Issa, L.

AU - Bisson, J.L.

AU - Domracheva, A.C.

AU - De Castro, K.F.

AU - Corrigan, A.M.

AU - Cran, H.R.

AU - Crawford, J.T.

AU - Cutter, S.M.

AU - Keenan, L.D.

AU - Donelan, E.M.

AU - Faramade, I.A.

AU - Reynoso, E.F.

AU - Fotopoulou, E.

AU - Fruean, S.N.

AU - Gallardo-Arrieta, F.

AU - Glebova, O.

AU - Häfelin Manrique, R.F.

AU - Henriques, J.J.G.P.

AU - Ignatenko, N.

AU - Koenig, D.

AU - Lanza-Perea, M.

AU - Lobetti, R.

AU - Lopezquintana, A.M.

AU - Losfelt, T.

AU - Marino, G.

AU - Martincorena, I.

AU - Castañeda, S.M.

AU - Martínez-López, M.F.

AU - Meyer, M.

AU - Nakanwagi, B.

AU - De Nardi, A.B.

AU - Neunzig, W.

AU - Nixon, S.J.

AU - Onsare, M.M.

AU - Ortega-Pacheco, A.

AU - Peleteiro, M.C.

AU - Pye, R.J.

AU - Reece, J.F.

AU - Gutierrez, J.R.

AU - Sadia, H.

AU - Schmeling, S.K.

AU - Shamanova, O.

AU - Ssuna, R.K.

AU - Steenland-Smitsvitich, A.E.

AU - Ngoka, I.T.

AU - Vitǎlaru, B.A.

AU - De Vos, A.P.

AU - De Vos, J.P.

AU - Walkinton, O.

AU - Wedge, D.C.

AU - Wehrle-Martinez, A.S.

AU - Van Der Wel, M.G.

AU - Widdowson, S.A.

AU - Murchison, E.P.

PY - 2016/5/17

Y1 - 2016/5/17

N2 - Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

AB - Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

U2 - 10.7554/eLife.14552

DO - 10.7554/eLife.14552

M3 - Article

SN - 2050-084X

VL - 5

JO - eLife

JF - eLife

ER -

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Abstract

Research Beacons, Institutes and Platforms

UN SDGs

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