Mixed micelles of structurally related antidepressant drugs

F. Sarmiento; J. L. López-Fontán; G. Prieto; D. Attwood; V. Mosquera

doi:10.1007/s003960050194

Mixed micelles of structurally related antidepressant drugs

F. Sarmiento, J. L. López-Fontán, G. Prieto, D. Attwood, V. Mosquera

Research output: Contribution to journal › Article › peer-review

Abstract

The composition of micelles in a binary mixture of the amphiphilic antidepressant drugs imipramine hydrochloride and clomipramine hydrochloride has been determined from an analysis of the variation of the critical micelle concentration from conductivity techniques as a function of solution composition. The equilibrium distribution of components between micelle and monomer phases was evaluated using a theoretical treatment based on excess thermodynamic quantities. The nonideality of mixing, expressed in terms of the interaction parameter β, was appreciable in systems containing low imipramine mole fractions, suggesting differences in the packing characteristics within micelles of these two drugs.

Original language	English
Pages (from-to)	1144-1147
Number of pages	3
Journal	Colloid and Polymer Science
Volume	275
Issue number	12
DOIs	https://doi.org/10.1007/s003960050194
Publication status	Published - Dec 1997

Keywords

Critical micelle concentration
Drugs
Mixed micelles

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10.1007/s003960050194

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title = "Mixed micelles of structurally related antidepressant drugs",

abstract = "The composition of micelles in a binary mixture of the amphiphilic antidepressant drugs imipramine hydrochloride and clomipramine hydrochloride has been determined from an analysis of the variation of the critical micelle concentration from conductivity techniques as a function of solution composition. The equilibrium distribution of components between micelle and monomer phases was evaluated using a theoretical treatment based on excess thermodynamic quantities. The nonideality of mixing, expressed in terms of the interaction parameter β, was appreciable in systems containing low imipramine mole fractions, suggesting differences in the packing characteristics within micelles of these two drugs.",

keywords = "Critical micelle concentration, Drugs, Mixed micelles",

author = "F. Sarmiento and L{\'o}pez-Font{\'a}n, {J. L.} and G. Prieto and D. Attwood and V. Mosquera",

year = "1997",

month = dec,

doi = "10.1007/s003960050194",

language = "English",

volume = "275",

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journal = "Colloid and Polymer Science",

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T1 - Mixed micelles of structurally related antidepressant drugs

AU - Sarmiento, F.

AU - López-Fontán, J. L.

AU - Prieto, G.

AU - Attwood, D.

AU - Mosquera, V.

PY - 1997/12

Y1 - 1997/12

N2 - The composition of micelles in a binary mixture of the amphiphilic antidepressant drugs imipramine hydrochloride and clomipramine hydrochloride has been determined from an analysis of the variation of the critical micelle concentration from conductivity techniques as a function of solution composition. The equilibrium distribution of components between micelle and monomer phases was evaluated using a theoretical treatment based on excess thermodynamic quantities. The nonideality of mixing, expressed in terms of the interaction parameter β, was appreciable in systems containing low imipramine mole fractions, suggesting differences in the packing characteristics within micelles of these two drugs.

AB - The composition of micelles in a binary mixture of the amphiphilic antidepressant drugs imipramine hydrochloride and clomipramine hydrochloride has been determined from an analysis of the variation of the critical micelle concentration from conductivity techniques as a function of solution composition. The equilibrium distribution of components between micelle and monomer phases was evaluated using a theoretical treatment based on excess thermodynamic quantities. The nonideality of mixing, expressed in terms of the interaction parameter β, was appreciable in systems containing low imipramine mole fractions, suggesting differences in the packing characteristics within micelles of these two drugs.

KW - Critical micelle concentration

KW - Drugs

KW - Mixed micelles

U2 - 10.1007/s003960050194

DO - 10.1007/s003960050194

M3 - Article

SN - 1435-1536

VL - 275

SP - 1144

EP - 1147

JO - Colloid and Polymer Science

JF - Colloid and Polymer Science

IS - 12

ER -

Mixed micelles of structurally related antidepressant drugs

Abstract

Keywords

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