Mixed micelles of structurally related antidepressant drugs

F. Sarmiento, J. L. López-Fontán, G. Prieto, D. Attwood, V. Mosquera

    Research output: Contribution to journalArticlepeer-review


    The composition of micelles in a binary mixture of the amphiphilic antidepressant drugs imipramine hydrochloride and clomipramine hydrochloride has been determined from an analysis of the variation of the critical micelle concentration from conductivity techniques as a function of solution composition. The equilibrium distribution of components between micelle and monomer phases was evaluated using a theoretical treatment based on excess thermodynamic quantities. The nonideality of mixing, expressed in terms of the interaction parameter β, was appreciable in systems containing low imipramine mole fractions, suggesting differences in the packing characteristics within micelles of these two drugs.
    Original languageEnglish
    Pages (from-to)1144-1147
    Number of pages3
    JournalColloid and Polymer Science
    Issue number12
    Publication statusPublished - Dec 1997


    • Critical micelle concentration
    • Drugs
    • Mixed micelles


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