Modeling infectious disease dynamics in the complex landscape of global health

Hans Heesterbeek, Roy M. Anderson, Viggo Andreasen, Shweta Bansal, Daniela De Angelis, Chris Dye, Ken T. D. Eames, W. John Edmunds, Simon D. W. Frost, Sebastian Funk, T. Deirdre Hollingsworth, Thomas House, Valerie Isham, Petra Klepac, Justin Lessler, James O. Lloyd-Smith, C. Jessica E. Metcalf, Denis Mollison, Lorenzo Pellis, Juliet R. C. PulliamMick G. Roberts, Cecile Viboud, Isaac Newton Institute IDD Collaboration

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Despite some notable successes in the control of infectious diseases, transmissible pathogens still pose an enormous threat to human and animal health. The ecological and evolutionary dynamics of infections play out on a wide range of interconnected temporal, organizational, and spatial scales, which span hours to months, cells to ecosystems, and local to global spread. Moreover, some pathogens are directly transmitted between individuals of a single species, whereas others circulate among multiple hosts, need arthropod vectors, or can survive in environmental reservoirs. Many factors, including increasing antimicrobial resistance, increased human connectivity and changeable human behavior, elevate prevention and control from matters of national policy to international challenge. In the face of this complexity, mathematical models offer valuable tools for synthesizing information to understand epidemiological patterns, and for developing quantitative evidence for decision-making in global health.
    Original languageEnglish
    Number of pages12
    JournalScience
    Volume347
    Issue number6227
    DOIs
    Publication statusPublished - Mar 2015

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