Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear

A. L. Hazel; D. M. Grzybowski; M. H. Friedman

doi:10.1114/1.1560633

Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear

A. L. Hazel, D. M. Grzybowski, M. H. Friedman

Research output: Contribution to journal › Article › peer-review

Abstract

An attempt was made to investigate the hypothesis that an important fraction of the uptake of macromolecules by the arterial wall occurs while the endothelium is adapting to changes in its hemodynamic environment. The investigation consisted of in vivo experiments in swine. Results are interpreted in terms of an ad hoc mathematical model of the hypothesized permeability response.

Original language	English
Pages (from-to)	412-419
Number of pages	7
Journal	Annals of Biomedical Engineering
Volume	31
Issue number	4
DOIs	https://doi.org/10.1114/1.1560633
Publication status	Published - 2003

Keywords

Atherogenesis
Endothelium
Hemodynamics
Wall shear stress

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title = "Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear",

abstract = "An attempt was made to investigate the hypothesis that an important fraction of the uptake of macromolecules by the arterial wall occurs while the endothelium is adapting to changes in its hemodynamic environment. The investigation consisted of in vivo experiments in swine. Results are interpreted in terms of an ad hoc mathematical model of the hypothesized permeability response.",

keywords = "Atherogenesis, Endothelium, Hemodynamics, Wall shear stress",

author = "Hazel, {A. L.} and Grzybowski, {D. M.} and Friedman, {M. H.}",

year = "2003",

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language = "English",

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AU - Hazel, A. L.

AU - Grzybowski, D. M.

AU - Friedman, M. H.

PY - 2003

Y1 - 2003

N2 - An attempt was made to investigate the hypothesis that an important fraction of the uptake of macromolecules by the arterial wall occurs while the endothelium is adapting to changes in its hemodynamic environment. The investigation consisted of in vivo experiments in swine. Results are interpreted in terms of an ad hoc mathematical model of the hypothesized permeability response.

AB - An attempt was made to investigate the hypothesis that an important fraction of the uptake of macromolecules by the arterial wall occurs while the endothelium is adapting to changes in its hemodynamic environment. The investigation consisted of in vivo experiments in swine. Results are interpreted in terms of an ad hoc mathematical model of the hypothesized permeability response.

KW - Atherogenesis

KW - Endothelium

KW - Hemodynamics

KW - Wall shear stress

U2 - 10.1114/1.1560633

DO - 10.1114/1.1560633

M3 - Article

SN - 1573-9686

VL - 31

SP - 412

EP - 419

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - 4

ER -

Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear

Abstract

Keywords

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