Modification of β-sheet forming peptide hydrophobic face: effect on self-assembly and gelation

Mohamed Elsawy, Andrew Smith, Nigel Hodson, Adam Squires, Aline Saiani, Alberto Saiani

    Research output: Contribution to journalArticlepeer-review


    ß-sheet forming peptides have attracted significant interest for the design of hydrogels for biomedical applications. One of the main challenges is the control and understanding of the correlations between peptide molecular structure, the morphology, and topology of the fiber and network formed as well as the macroscopic properties of the hydrogel obtained. In this work, we have investigated the effect that functionalizing these peptides through their hydrophobic face has on their self-assembly and gelation. Our results show that the modification of the hydrophobic face results in a partial loss of the extended
    ß-sheet conformation of the peptide and a significant change in fiber morphology from straight to kinked. As a consequence the ability of these fibers to associate along their length and form large bundles is reduced leading. These structural changes (fiber structure and network topology)
    significantly affect the mechanical properties of the hydrogels (shear modulus and elasticity).
    Original languageEnglish
    Pages (from-to)4917-4923
    Number of pages7
    Issue number19
    Publication statusPublished - 18 Apr 2016


    Dive into the research topics of 'Modification of β-sheet forming peptide hydrophobic face: effect on self-assembly and gelation'. Together they form a unique fingerprint.

    Cite this