Abstract
Sunscreen preparations containing 5-methoxypsoralen at 25μg/ml and 50μg/ml, and the appropriate vehicle only, sunscreen only, and 5-methoxypsoralen only controls, were assessed for tumorigenic potential in hairless albino mice exposed to solar simulated radiation for a period of 44-46 weeks. Some animals were observed for a 15 week postirradiation period. A wide range of statistical analyses has shown that, during the course of irradiation, the inclusion of sunscreens eliminates the enhancement of phototumorigenesis and malignancy that is normally observed with 5-methoxypsoralen. There was, however, some indication of increased risk at the end of the postirradiation follow-up period. Possible reasons for the protective effect of the sunscreens and the relevance of these data to the assessment of human risk are discussed. © 1987.
Original language | English |
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Pages (from-to) | 611-617 |
Number of pages | 6 |
Journal | Journal of Investigative Dermatology |
Volume | 89 |
Issue number | 6 |
Publication status | Published - Dec 1987 |