Modification of 5-methoxypsoralen phototumorigenesis by UVB sunscreens: A statistical and histologic study in the hairless albino mouse

Antony R. Young, Neil K. Gibbs, Ian A. Magnus

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Sunscreen preparations containing 5-methoxypsoralen at 25μg/ml and 50μg/ml, and the appropriate vehicle only, sunscreen only, and 5-methoxypsoralen only controls, were assessed for tumorigenic potential in hairless albino mice exposed to solar simulated radiation for a period of 44-46 weeks. Some animals were observed for a 15 week postirradiation period. A wide range of statistical analyses has shown that, during the course of irradiation, the inclusion of sunscreens eliminates the enhancement of phototumorigenesis and malignancy that is normally observed with 5-methoxypsoralen. There was, however, some indication of increased risk at the end of the postirradiation follow-up period. Possible reasons for the protective effect of the sunscreens and the relevance of these data to the assessment of human risk are discussed. © 1987.
    Original languageEnglish
    Pages (from-to)611-617
    Number of pages6
    JournalJournal of Investigative Dermatology
    Volume89
    Issue number6
    Publication statusPublished - Dec 1987

    Fingerprint

    Dive into the research topics of 'Modification of 5-methoxypsoralen phototumorigenesis by UVB sunscreens: A statistical and histologic study in the hairless albino mouse'. Together they form a unique fingerprint.

    Cite this