Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome

Moaz A. Mojaddidi; Mohammed S. Ahmed; Razwan Ali; Maria Jeziorska; Ahmed Al-Sunni; Niels O B Thomsen; Lars B. Dahlin; Rayaz A. Malik

doi:10.1007/s00125-014-3271-3

Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome

Moaz A. Mojaddidi, Mohammed S. Ahmed, Razwan Ali, Maria Jeziorska, Ahmed Al-Sunni, Niels O B Thomsen, Lars B. Dahlin, Rayaz A. Malik

Research output: Contribution to journal › Article › peer-review

Abstract

Aims/hypothesis: We sought to establish the molecular and pathological changes predisposing diabetic and non-diabetic patients to the development of carpal tunnel syndrome (CTS). Methods: The posterior interosseous nerve (PIN) was biopsied in 25 diabetic and 19 non-diabetic patients undergoing carpal tunnel decompression for CTS. Detailed morphometric and immunohistological analyses were performed in the nerve biopsy. Results: In diabetic patients median nerve distal motor latency was prolonged (p

Original language	English
Pages (from-to)	1711-1719
Number of pages	8
Journal	Diabetologia
Volume	57
Issue number	8
DOIs	https://doi.org/10.1007/s00125-014-3271-3
Publication status	Published - 2014

Keywords

Carpal tunnel syndrome
Diabetes
HIF-1α
Microangiopathy
Myelinated fibre
Neuropathy
Unmyelinated fibre
VEGF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-014-3271-3

http://link.springer.de/link/service/journals/00125/index.htm

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title = "Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome",

abstract = "Aims/hypothesis: We sought to establish the molecular and pathological changes predisposing diabetic and non-diabetic patients to the development of carpal tunnel syndrome (CTS). Methods: The posterior interosseous nerve (PIN) was biopsied in 25 diabetic and 19 non-diabetic patients undergoing carpal tunnel decompression for CTS. Detailed morphometric and immunohistological analyses were performed in the nerve biopsy. Results: In diabetic patients median nerve distal motor latency was prolonged (p",

keywords = "Carpal tunnel syndrome, Diabetes, HIF-1α, Microangiopathy, Myelinated fibre, Neuropathy, Unmyelinated fibre, VEGF",

author = "Mojaddidi, {Moaz A.} and Ahmed, {Mohammed S.} and Razwan Ali and Maria Jeziorska and Ahmed Al-Sunni and Thomsen, {Niels O B} and Dahlin, {Lars B.} and Malik, {Rayaz A.}",

year = "2014",

doi = "10.1007/s00125-014-3271-3",

language = "English",

volume = "57",

pages = "1711--1719",

journal = "Diabetologia",

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TY - JOUR

T1 - Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome

AU - Mojaddidi, Moaz A.

AU - Ahmed, Mohammed S.

AU - Ali, Razwan

AU - Jeziorska, Maria

AU - Al-Sunni, Ahmed

AU - Thomsen, Niels O B

AU - Dahlin, Lars B.

AU - Malik, Rayaz A.

PY - 2014

Y1 - 2014

N2 - Aims/hypothesis: We sought to establish the molecular and pathological changes predisposing diabetic and non-diabetic patients to the development of carpal tunnel syndrome (CTS). Methods: The posterior interosseous nerve (PIN) was biopsied in 25 diabetic and 19 non-diabetic patients undergoing carpal tunnel decompression for CTS. Detailed morphometric and immunohistological analyses were performed in the nerve biopsy. Results: In diabetic patients median nerve distal motor latency was prolonged (p

AB - Aims/hypothesis: We sought to establish the molecular and pathological changes predisposing diabetic and non-diabetic patients to the development of carpal tunnel syndrome (CTS). Methods: The posterior interosseous nerve (PIN) was biopsied in 25 diabetic and 19 non-diabetic patients undergoing carpal tunnel decompression for CTS. Detailed morphometric and immunohistological analyses were performed in the nerve biopsy. Results: In diabetic patients median nerve distal motor latency was prolonged (p

KW - Carpal tunnel syndrome

KW - Diabetes

KW - HIF-1α

KW - Microangiopathy

KW - Myelinated fibre

KW - Neuropathy

KW - Unmyelinated fibre

KW - VEGF

U2 - 10.1007/s00125-014-3271-3

DO - 10.1007/s00125-014-3271-3

M3 - Article

C2 - 24865616

SN - 1432-0428

VL - 57

SP - 1711

EP - 1719

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome

Abstract

Keywords

UN SDGs

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