TY - JOUR
T1 - Molecular chaperones as regulatory elements of cellular networks
AU - Papp, Balazs
AU - Soti, Csaba
AU - Pál, Csaba
AU - Papp, Balázs
AU - Csermely, Péter
PY - 2005/4
Y1 - 2005/4
N2 - Molecular chaperones help hundreds of signaling molecules to keep their activation-competent state, and regulate various signaling processes ranging from signaling at the plasma membrane to transcription. Besides these specific regulatory roles, recent studies have revealed that chaperones act as genetic buffers stabilizing the phenotypes of various cells and organisms. This may be related to their low affinity for the proteins they interact with, which means that they represent weak links in protein networks. Chaperones may uncouple protein, signaling, membrane, organelle and transcriptional networks during stress, which gives the cell additional protection. The same networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies. © 2005 Elsevier Ltd. All rights reserved.
AB - Molecular chaperones help hundreds of signaling molecules to keep their activation-competent state, and regulate various signaling processes ranging from signaling at the plasma membrane to transcription. Besides these specific regulatory roles, recent studies have revealed that chaperones act as genetic buffers stabilizing the phenotypes of various cells and organisms. This may be related to their low affinity for the proteins they interact with, which means that they represent weak links in protein networks. Chaperones may uncouple protein, signaling, membrane, organelle and transcriptional networks during stress, which gives the cell additional protection. The same networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies. © 2005 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.ceb.2005.02.012
DO - 10.1016/j.ceb.2005.02.012
M3 - Article
C2 - 15780599
SN - 0955-0674
VL - 17
SP - 210
EP - 215
JO - Current opinion in cell biology
JF - Current opinion in cell biology
IS - 2
ER -