Molecular control of endothelial cell behaviour during blood vessel morphogenesis

Shane P. Herbert, Didier Y R Stainier

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The vertebrate vasculature forms an extensive branched network of blood vessels that supplies tissues with nutrients and oxygen. During vascular development, coordinated control of endothelial cell behaviour at the levels of cell migration, proliferation, polarity, differentiation and cellg-cell communication is critical for functional blood vessel morphogenesis. Recent data uncover elaborate transcriptional, post-transcriptional and post-translational mechanisms that fine-tune key signalling pathways (such as the vascular endothelial growth factor and Notch pathways) to control endothelial cell behaviour during blood vessel sprouting (angiogenesis). These emerging frameworks controlling angiogenesis provide unique insights into fundamental biological processes common to other systems, such as tissue branching morphogenesis, mechanotransduction and tubulogenesis. © 2011 Macmillan Publishers Limited. All rights reserved.
    Original languageEnglish
    Pages (from-to)551-564
    Number of pages13
    JournalNature Reviews Molecular Cell Biology
    Volume12
    Issue number9
    DOIs
    Publication statusPublished - Sept 2011

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