Molecular mechanisms of metastasis in prostate cancer

Noel W. Clarke, Claire A. Hart, Mick D. Brown

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    Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.
    Original languageEnglish
    Pages (from-to)57-67
    Number of pages10
    JournalAsian Journal of Andrology
    Issue number1
    Publication statusPublished - 2009


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