Molecular mechanisms of metastasis in prostate cancer

Noel W. Clarke; Claire A. Hart; Mick D. Brown

doi:10.1038/aja.2008.29

Molecular mechanisms of metastasis in prostate cancer

Noel W. Clarke, Claire A. Hart, Mick D. Brown

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Abstract

Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.

Original language	English
Pages (from-to)	57-67
Number of pages	10
Journal	Asian Journal of Andrology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/aja.2008.29
Publication status	Published - 2009

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title = "Molecular mechanisms of metastasis in prostate cancer",

abstract = "Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.",

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AU - Brown, Mick D.

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AB - Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.

U2 - 10.1038/aja.2008.29

DO - 10.1038/aja.2008.29

M3 - Article

VL - 11

SP - 57

EP - 67

JO - Asian Journal of Andrology

JF - Asian Journal of Andrology

SN - 1745-7262

IS - 1

ER -

Molecular mechanisms of metastasis in prostate cancer

Abstract

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