Molecular motors and the Golgi complex: Staying put and moving through

Kim Brownhill; Laura Wood; Viki Allan

doi:10.1016/j.semcdb.2009.03.019

Molecular motors and the Golgi complex: Staying put and moving through

Kim Brownhill, Laura Wood, Viki Allan

Research output: Contribution to journal › Article › peer-review

Abstract

The Golgi apparatus is a highly dynamic organelle through which nascent proteins released from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified within the Golgi and subsequently packaged into carriers for transport to a variety of cellular destinations. This transit of proteins, as well as the maintenance of Golgi structure and position, is highly dependent upon the actin and microtubule cytoskeletons and their associated molecular motors. Here we review how motors contribute to the correct functioning of the Golgi in higher eukaryotes and discuss the secretory pathway as a model system for studying cooperation between motor proteins. © 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	784-792
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.semcdb.2009.03.019
Publication status	Published - Sept 2009

Keywords

Actin
Cell migration
Dynein
Golgi
Kinesin
Microtubule
Myosin
Secretion

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10.1016/j.semcdb.2009.03.019

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abstract = "The Golgi apparatus is a highly dynamic organelle through which nascent proteins released from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified within the Golgi and subsequently packaged into carriers for transport to a variety of cellular destinations. This transit of proteins, as well as the maintenance of Golgi structure and position, is highly dependent upon the actin and microtubule cytoskeletons and their associated molecular motors. Here we review how motors contribute to the correct functioning of the Golgi in higher eukaryotes and discuss the secretory pathway as a model system for studying cooperation between motor proteins. {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",

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author = "Kim Brownhill and Laura Wood and Viki Allan",

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T1 - Molecular motors and the Golgi complex: Staying put and moving through

AU - Brownhill, Kim

AU - Wood, Laura

AU - Allan, Viki

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AB - The Golgi apparatus is a highly dynamic organelle through which nascent proteins released from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified within the Golgi and subsequently packaged into carriers for transport to a variety of cellular destinations. This transit of proteins, as well as the maintenance of Golgi structure and position, is highly dependent upon the actin and microtubule cytoskeletons and their associated molecular motors. Here we review how motors contribute to the correct functioning of the Golgi in higher eukaryotes and discuss the secretory pathway as a model system for studying cooperation between motor proteins. © 2009 Elsevier Ltd. All rights reserved.

KW - Actin

KW - Cell migration

KW - Dynein

KW - Golgi

KW - Kinesin

KW - Microtubule

KW - Myosin

KW - Secretion

U2 - 10.1016/j.semcdb.2009.03.019

DO - 10.1016/j.semcdb.2009.03.019

M3 - Article

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VL - 20

SP - 784

EP - 792

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 7

ER -

Molecular motors and the Golgi complex: Staying put and moving through

Abstract

Keywords

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