Monitoring working areas for cytotoxic drugs: Analytical techniques developed to provide risk management of cytotoxic preparative activities

Chemotherapy remains the best systemic treatment for cancer but the effects of cytotoxic agents on normal healthy cells presents occupational risks to pharmacy and clinical staff. Discussion about safe handling of cytotoxic drugs in UK’s NHS pharmacy preparation facilities has been ongoing for many years.[1-3] As recently as 20 years ago cytotoxic preparation operated in clean room facilities equipped only with Class II microbiological safety cabinets. Since that time there was a steady move towards barrier technology, such as that provided by negative pressure isolators, which remain the recommended devices for operator and product protection.[4] This development has greatly improved safety levels and reduced risks for NHS pharmacy staff who handle these products. There is still concern, however, for those people who may be exposed to very low levels on a regular basis.