Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

Nicholas Turner; Elaine O'Reilly; C. Iglesias

doi:10.1002/cctc.201300990

Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

Nicholas Turner, Elaine O'Reilly, C. Iglesias

Research output: Contribution to journal › Article › peer-review

Abstract

Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.

Original language	English
Pages (from-to)	992-995
Journal	ChemCatChem
Volume	6
Issue number	4
DOIs	https://doi.org/10.1002/cctc.201300990
Publication status	Published - 2014

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title = "Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines",

abstract = "Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.",

author = "Nicholas Turner and Elaine O'Reilly and C. Iglesias",

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AB - Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.

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DO - 10.1002/cctc.201300990

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JO - ChemCatChem

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IS - 4

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Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

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