Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

Nicholas Turner; Elaine O'Reilly; C. Iglesias

doi:10.1002/cctc.201300990

Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

Nicholas Turner, Elaine O'Reilly, C. Iglesias

Research output: Contribution to journal › Article › peer-review

Abstract

Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.

Original language	English
Pages (from-to)	992-995
Journal	ChemCatChem
Volume	6
Issue number	4
DOIs	https://doi.org/10.1002/cctc.201300990
Publication status	Published - 2014

Access to Document

10.1002/cctc.201300990

Cite this

@article{d6ca6f96773a4869b9ef378ddf4dbe62,

title = "Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines",

abstract = "Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 \% ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 \% conversion.",

author = "Nicholas Turner and Elaine O'Reilly and C. Iglesias",

year = "2014",

doi = "10.1002/cctc.201300990",

language = "English",

volume = "6",

pages = "992--995",

journal = "ChemCatChem",

issn = "1867-3880",

publisher = "John Wiley \& Sons Ltd",

number = "4",

}

TY - JOUR

T1 - Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

AU - Turner, Nicholas

AU - O'Reilly, Elaine

AU - Iglesias, C.

PY - 2014

Y1 - 2014

N2 - Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.

AB - Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.

UR - https://www.scopus.com/pages/publications/84898663122

U2 - 10.1002/cctc.201300990

DO - 10.1002/cctc.201300990

M3 - Article

SN - 1867-3880

VL - 6

SP - 992

EP - 995

JO - ChemCatChem

JF - ChemCatChem

IS - 4

ER -

Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

Abstract

Access to Document

Other files and links

Fingerprint

Cite this