More than meets the ISG15: emerging roles in the DNA damage response and beyond

Zac Sandy; Isabelle Cristine Da Costa; Christine K. Schmidt

doi:10.3390/biom10111557

More than meets the ISG15: emerging roles in the DNA damage response and beyond

Zac Sandy, Isabelle Cristine Da Costa, Christine K. Schmidt

Research output: Contribution to journal › Review article › peer-review

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Abstract

Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-translational modifications that range from
13 simple additions of chemical moieties to the conjugation of ubiquitin-like proteins (UBLs). Interferon Stimulated Gene 15 (ISG15) is one such UBL. While classically thought of as a component of antiviral immunity, ISG15 has recently emerged as a regulator of genome stability, with key roles in the DNA damage response (DDR) to modulate p53 signalling and error-free DNA replication. Additional proteomic analyses and cancer-focused studies hint at wider-reaching, uncharacterised functions for ISG15 in genome stability. We review these recent discoveries and highlight future
19 perspectives to increase our understanding of this multifaceted UBL in health and disease.

Original language	English
Journal	Biomolecules
DOIs	https://doi.org/10.3390/biom10111557
Publication status	Published - 15 Nov 2020

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

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10.3390/biom10111557Licence: CC BY

biomolecules-10-01557Final published version, 6.1 MBLicence: CC BY

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title = "More than meets the ISG15: emerging roles in the DNA damage response and beyond",

abstract = "Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-translational modifications that range from13 simple additions of chemical moieties to the conjugation of ubiquitin-like proteins (UBLs). Interferon Stimulated Gene 15 (ISG15) is one such UBL. While classically thought of as a component of antiviral immunity, ISG15 has recently emerged as a regulator of genome stability, with key roles in the DNA damage response (DDR) to modulate p53 signalling and error-free DNA replication. Additional proteomic analyses and cancer-focused studies hint at wider-reaching, uncharacterised functions for ISG15 in genome stability. We review these recent discoveries and highlight future19 perspectives to increase our understanding of this multifaceted UBL in health and disease.",

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AU - Sandy, Zac

AU - Da Costa, Isabelle Cristine

AU - Schmidt, Christine K.

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N2 - Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-translational modifications that range from13 simple additions of chemical moieties to the conjugation of ubiquitin-like proteins (UBLs). Interferon Stimulated Gene 15 (ISG15) is one such UBL. While classically thought of as a component of antiviral immunity, ISG15 has recently emerged as a regulator of genome stability, with key roles in the DNA damage response (DDR) to modulate p53 signalling and error-free DNA replication. Additional proteomic analyses and cancer-focused studies hint at wider-reaching, uncharacterised functions for ISG15 in genome stability. We review these recent discoveries and highlight future19 perspectives to increase our understanding of this multifaceted UBL in health and disease.

AB - Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-translational modifications that range from13 simple additions of chemical moieties to the conjugation of ubiquitin-like proteins (UBLs). Interferon Stimulated Gene 15 (ISG15) is one such UBL. While classically thought of as a component of antiviral immunity, ISG15 has recently emerged as a regulator of genome stability, with key roles in the DNA damage response (DDR) to modulate p53 signalling and error-free DNA replication. Additional proteomic analyses and cancer-focused studies hint at wider-reaching, uncharacterised functions for ISG15 in genome stability. We review these recent discoveries and highlight future19 perspectives to increase our understanding of this multifaceted UBL in health and disease.

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DO - 10.3390/biom10111557

M3 - Review article

SN - 2218-273X

JO - Biomolecules

JF - Biomolecules

ER -

More than meets the ISG15: emerging roles in the DNA damage response and beyond

Abstract

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UN SDGs

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