Morphological characteristics of the sinus node on postmortem tissue.

Filip Virgil Perde, Andrew Atkinson, Joseph Yanni, Dan Dermengiu, Halina Dobrzynski

    Research output: Contribution to journalArticlepeer-review


    The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of postmortem forensic investigation and provide information related to the diagnostic of cardiac arrhythmia. I described the stages of this investigation, with dissection, preservation and analysis that included classical histology, immunohistochemistry, confocal microscope, microdissection, RIN testing, mRNA expression obtaining a precise morphofunctional location of the sinus node.
    Original languageEnglish
    JournalFolia morphologica
    Publication statusPublished - 5 Oct 2015


    • Messenger RNA
    • autopsy
    • connexin 43


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