Morphological characteristics of the sinus node on postmortem tissue.

Filip Virgil Perde; Andrew Atkinson; Joseph Yanni; Dan Dermengiu; Halina Dobrzynski

doi:10.5603/FM.a2015.0087

Morphological characteristics of the sinus node on postmortem tissue.

Filip Virgil Perde, Andrew Atkinson, Joseph Yanni, Dan Dermengiu, Halina Dobrzynski

Research output: Contribution to journal › Article › peer-review

Abstract

The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of postmortem forensic investigation and provide information related to the diagnostic of cardiac arrhythmia. I described the stages of this investigation, with dissection, preservation and analysis that included classical histology, immunohistochemistry, confocal microscope, microdissection, RIN testing, mRNA expression obtaining a precise morphofunctional location of the sinus node.

Original language	English
Journal	Folia morphologica
DOIs	https://doi.org/10.5603/FM.a2015.0087
Publication status	Published - 5 Oct 2015

Keywords

Messenger RNA
autopsy
connexin 43

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title = "Morphological characteristics of the sinus node on postmortem tissue.",

abstract = "The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of postmortem forensic investigation and provide information related to the diagnostic of cardiac arrhythmia. I described the stages of this investigation, with dissection, preservation and analysis that included classical histology, immunohistochemistry, confocal microscope, microdissection, RIN testing, mRNA expression obtaining a precise morphofunctional location of the sinus node.",

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AU - Perde, Filip Virgil

AU - Atkinson, Andrew

AU - Yanni, Joseph

AU - Dermengiu, Dan

AU - Dobrzynski, Halina

PY - 2015/10/5

Y1 - 2015/10/5

N2 - The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of postmortem forensic investigation and provide information related to the diagnostic of cardiac arrhythmia. I described the stages of this investigation, with dissection, preservation and analysis that included classical histology, immunohistochemistry, confocal microscope, microdissection, RIN testing, mRNA expression obtaining a precise morphofunctional location of the sinus node.

AB - The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of postmortem forensic investigation and provide information related to the diagnostic of cardiac arrhythmia. I described the stages of this investigation, with dissection, preservation and analysis that included classical histology, immunohistochemistry, confocal microscope, microdissection, RIN testing, mRNA expression obtaining a precise morphofunctional location of the sinus node.

KW - Messenger RNA

KW - autopsy

KW - connexin 43

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DO - 10.5603/FM.a2015.0087

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SN - 0015-5659

JO - Folia morphologica

JF - Folia morphologica

ER -

Morphological characteristics of the sinus node on postmortem tissue.

Abstract

Keywords

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