Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation

G. M. Marsh; J. M. Buchanich; S. Zimmerman; Y. Liu; L. C. Balmert; J. Graves; K. J. Kennedy; N. A. Esmen; H. Moshammer; P. Morfeld; T. Erren; J. V. Gross; M. Yong; M. Svartengren; H. Westberg; D. McElvenny; J. W. Cherrie

doi:10.1097/jom.0000000000001151

Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation

G. M. Marsh, J. M. Buchanich, S. Zimmerman, Y. Liu, L. C. Balmert, J. Graves, K. J. Kennedy, N. A. Esmen, H. Moshammer, P. Morfeld, T. Erren, J. V. Gross, M. Yong, M. Svartengren, H. Westberg, D. McElvenny, J. W. Cherrie

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Based on a pooled analysis of data from an international study, evaluate total and cause-specific mortality among hardmetal production workers with emphasis on lung cancer. METHODS: Study members were 32,354 workers from three companies and 17 manufacturing sites in five countries. We computed standardized mortality ratios and evaluated exposure-response via relative risk regression analysis. RESULTS: Among long-term workers, we observed overall deficits or slight excesses in deaths for total mortality, all cancers, and lung cancer and found no evidence of any exposure-response relationships for lung cancer. CONCLUSIONS: We found no evidence that duration, average intensity, or cumulative exposure to tungsten, cobalt, or nickel, at levels experienced by the workers examined, increases lung cancer mortality risks. We also found no evidence that work in these facilities increased mortality risks from any other causes of death.

Original language	English
Pages (from-to)	e342-e364
Journal	Journal of Occupational and Environmental Medicine
Volume	59
Issue number	12
DOIs	https://doi.org/10.1097/jom.0000000000001151
Publication status	Published - 1 Dec 2017

Keywords

Adult Alloys/*adverse effects Cause of Death Chemical Industry/statistics & numerical data Cobalt/*adverse effects Female Humans Lung Neoplasms/chemically induced/*mortality Male Occupational Diseases/*mortality Occupational Exposure/*adverse effects/statistics & numerical data Risk Factors Tungsten/*adverse effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://researchportal.hw.ac.uk/files/16089768/Accepted_UK_Manuscript.pdf

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Marsh, G. M., Buchanich, J. M., Zimmerman, S., Liu, Y., Balmert, L. C., Graves, J., Kennedy, K. J., Esmen, N. A., Moshammer, H., Morfeld, P., Erren, T., Gross, J. V., Yong, M., Svartengren, M., Westberg, H., McElvenny, D., & Cherrie, J. W. (2017). Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation. Journal of Occupational and Environmental Medicine, 59(12), e342-e364. https://doi.org/10.1097/jom.0000000000001151

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title = "Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation",

abstract = "OBJECTIVES: Based on a pooled analysis of data from an international study, evaluate total and cause-specific mortality among hardmetal production workers with emphasis on lung cancer. METHODS: Study members were 32,354 workers from three companies and 17 manufacturing sites in five countries. We computed standardized mortality ratios and evaluated exposure-response via relative risk regression analysis. RESULTS: Among long-term workers, we observed overall deficits or slight excesses in deaths for total mortality, all cancers, and lung cancer and found no evidence of any exposure-response relationships for lung cancer. CONCLUSIONS: We found no evidence that duration, average intensity, or cumulative exposure to tungsten, cobalt, or nickel, at levels experienced by the workers examined, increases lung cancer mortality risks. We also found no evidence that work in these facilities increased mortality risks from any other causes of death.",

keywords = "Adult Alloys/*adverse effects Cause of Death Chemical Industry/statistics & numerical data Cobalt/*adverse effects Female Humans Lung Neoplasms/chemically induced/*mortality Male Occupational Diseases/*mortality Occupational Exposure/*adverse effects/statistics & numerical data Risk Factors Tungsten/*adverse effects",

author = "Marsh, {G. M.} and Buchanich, {J. M.} and S. Zimmerman and Y. Liu and Balmert, {L. C.} and J. Graves and Kennedy, {K. J.} and Esmen, {N. A.} and H. Moshammer and P. Morfeld and T. Erren and Gross, {J. V.} and M. Yong and M. Svartengren and H. Westberg and D. McElvenny and Cherrie, {J. W.}",

note = "1536-5948 Marsh, Gary M Buchanich, Jeanine M Zimmerman, Sarah Liu, Yimeng Balmert, Lauren C Graves, Jessica Kennedy, Kathleen J Esmen, Nurtan A Moshammer, Hanns Morfeld, Peter Erren, Thomas Gross, Juliane Valerie Yong, Mei Svartengren, Magnus Westberg, Hakan McElvenny, Damien Cherrie, John W Journal Article Meta-Analysis United States J Occup Environ Med. 2017 Dec;59(12):e342-e364. doi: 10.1097/JOM.0000000000001151.",

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Marsh, GM, Buchanich, JM, Zimmerman, S, Liu, Y, Balmert, LC, Graves, J, Kennedy, KJ, Esmen, NA, Moshammer, H, Morfeld, P, Erren, T, Gross, JV, Yong, M, Svartengren, M, Westberg, H, McElvenny, D & Cherrie, JW 2017, 'Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation', Journal of Occupational and Environmental Medicine, vol. 59, no. 12, pp. e342-e364. https://doi.org/10.1097/jom.0000000000001151

TY - JOUR

T1 - Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation

AU - Marsh, G. M.

AU - Buchanich, J. M.

AU - Zimmerman, S.

AU - Liu, Y.

AU - Balmert, L. C.

AU - Graves, J.

AU - Kennedy, K. J.

AU - Esmen, N. A.

AU - Moshammer, H.

AU - Morfeld, P.

AU - Erren, T.

AU - Gross, J. V.

AU - Yong, M.

AU - Svartengren, M.

AU - Westberg, H.

AU - McElvenny, D.

AU - Cherrie, J. W.

N1 - 1536-5948 Marsh, Gary M Buchanich, Jeanine M Zimmerman, Sarah Liu, Yimeng Balmert, Lauren C Graves, Jessica Kennedy, Kathleen J Esmen, Nurtan A Moshammer, Hanns Morfeld, Peter Erren, Thomas Gross, Juliane Valerie Yong, Mei Svartengren, Magnus Westberg, Hakan McElvenny, Damien Cherrie, John W Journal Article Meta-Analysis United States J Occup Environ Med. 2017 Dec;59(12):e342-e364. doi: 10.1097/JOM.0000000000001151.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - OBJECTIVES: Based on a pooled analysis of data from an international study, evaluate total and cause-specific mortality among hardmetal production workers with emphasis on lung cancer. METHODS: Study members were 32,354 workers from three companies and 17 manufacturing sites in five countries. We computed standardized mortality ratios and evaluated exposure-response via relative risk regression analysis. RESULTS: Among long-term workers, we observed overall deficits or slight excesses in deaths for total mortality, all cancers, and lung cancer and found no evidence of any exposure-response relationships for lung cancer. CONCLUSIONS: We found no evidence that duration, average intensity, or cumulative exposure to tungsten, cobalt, or nickel, at levels experienced by the workers examined, increases lung cancer mortality risks. We also found no evidence that work in these facilities increased mortality risks from any other causes of death.

AB - OBJECTIVES: Based on a pooled analysis of data from an international study, evaluate total and cause-specific mortality among hardmetal production workers with emphasis on lung cancer. METHODS: Study members were 32,354 workers from three companies and 17 manufacturing sites in five countries. We computed standardized mortality ratios and evaluated exposure-response via relative risk regression analysis. RESULTS: Among long-term workers, we observed overall deficits or slight excesses in deaths for total mortality, all cancers, and lung cancer and found no evidence of any exposure-response relationships for lung cancer. CONCLUSIONS: We found no evidence that duration, average intensity, or cumulative exposure to tungsten, cobalt, or nickel, at levels experienced by the workers examined, increases lung cancer mortality risks. We also found no evidence that work in these facilities increased mortality risks from any other causes of death.

KW - Adult Alloys/adverse effects Cause of Death Chemical Industry/statistics & numerical data Cobalt/adverse effects Female Humans Lung Neoplasms/chemically induced/mortality Male Occupational Diseases/mortality Occupational Exposure/adverse effects/statistic

U2 - 10.1097/jom.0000000000001151

DO - 10.1097/jom.0000000000001151

M3 - Article

SN - 1076-2752

VL - 59

SP - e342-e364

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 12

ER -

Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data From an International Investigation

Abstract

Keywords

UN SDGs

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