Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case-Control Studies

D. M. McElvenny; L. A. MacCalman; A. Sleeuwenhoek; A. Davis; B. G. Miller; C. Alexander; H. Cowie; J. W. Cherrie; K. J. Kennedy; N. A. Esmen; S. D. Zimmerman; J. M. Buchanich; G. M. Marsh

doi:10.1097/jom.0000000000001036

Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case-Control Studies

D. M. McElvenny, L. A. MacCalman, A. Sleeuwenhoek, A. Davis, B. G. Miller, C. Alexander, H. Cowie, J. W. Cherrie, K. J. Kennedy, N. A. Esmen, S. D. Zimmerman, J. M. Buchanich, G. M. Marsh

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. RESULTS: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

Original language	English
Pages (from-to)	e275-e281
Journal	Journal of Occupational and Environmental Medicine
Volume	59
Issue number	12
DOIs	https://doi.org/10.1097/jom.0000000000001036
Publication status	Published - 1 Dec 2017

Keywords

Adult Alloys/*adverse effects Case-Control Studies Cause of Death Chemical Industry/statistics & numerical data Cobalt/*adverse effects Cohort Studies Female Humans Lung Neoplasms/chemically induced/*mortality Male Occupational Diseases/*mortality Occupational Exposure/*adverse effects/statistics & numerical data Risk Factors Tungsten/*adverse effects United Kingdom

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/jom.0000000000001036

https://researchportal.hw.ac.uk/files/16089768/Accepted_UK_Manuscript.pdf

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McElvenny, D. M., MacCalman, L. A., Sleeuwenhoek, A., Davis, A., Miller, B. G., Alexander, C., Cowie, H., Cherrie, J. W., Kennedy, K. J., Esmen, N. A., Zimmerman, S. D., Buchanich, J. M., & Marsh, G. M. (2017). Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case-Control Studies. Journal of Occupational and Environmental Medicine, 59(12), e275-e281. https://doi.org/10.1097/jom.0000000000001036

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abstract = "OBJECTIVE: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. RESULTS: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.",

keywords = "Adult Alloys/*adverse effects Case-Control Studies Cause of Death Chemical Industry/statistics & numerical data Cobalt/*adverse effects Cohort Studies Female Humans Lung Neoplasms/chemically induced/*mortality Male Occupational Diseases/*mortality Occupational Exposure/*adverse effects/statistics & numerical data Risk Factors Tungsten/*adverse effects United Kingdom",

author = "McElvenny, {D. M.} and MacCalman, {L. A.} and A. Sleeuwenhoek and A. Davis and Miller, {B. G.} and C. Alexander and H. Cowie and Cherrie, {J. W.} and Kennedy, {K. J.} and Esmen, {N. A.} and Zimmerman, {S. D.} and Buchanich, {J. M.} and Marsh, {G. M.}",

note = "1536-5948 McElvenny, Damien M MacCalman, Laura A Sleeuwenhoek, Anne Davis, Alice Miller, Brian G Alexander, Carla Cowie, Hilary Cherrie, John W Kennedy, Kathleen J Esmen, Nurtan A Zimmerman, Sarah D Buchanich, Jeanine M Marsh, Gary M Journal Article Research Support, Non-U.S. Gov't United States J Occup Environ Med. 2017 Dec;59(12):e275-e281. doi: 10.1097/JOM.0000000000001036.",

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McElvenny, DM, MacCalman, LA, Sleeuwenhoek, A, Davis, A, Miller, BG, Alexander, C, Cowie, H, Cherrie, JW, Kennedy, KJ, Esmen, NA, Zimmerman, SD, Buchanich, JM & Marsh, GM 2017, 'Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case-Control Studies', Journal of Occupational and Environmental Medicine, vol. 59, no. 12, pp. e275-e281. https://doi.org/10.1097/jom.0000000000001036

TY - JOUR

T1 - Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case-Control Studies

AU - McElvenny, D. M.

AU - MacCalman, L. A.

AU - Sleeuwenhoek, A.

AU - Davis, A.

AU - Miller, B. G.

AU - Alexander, C.

AU - Cowie, H.

AU - Cherrie, J. W.

AU - Kennedy, K. J.

AU - Esmen, N. A.

AU - Zimmerman, S. D.

AU - Buchanich, J. M.

AU - Marsh, G. M.

N1 - 1536-5948 McElvenny, Damien M MacCalman, Laura A Sleeuwenhoek, Anne Davis, Alice Miller, Brian G Alexander, Carla Cowie, Hilary Cherrie, John W Kennedy, Kathleen J Esmen, Nurtan A Zimmerman, Sarah D Buchanich, Jeanine M Marsh, Gary M Journal Article Research Support, Non-U.S. Gov't United States J Occup Environ Med. 2017 Dec;59(12):e275-e281. doi: 10.1097/JOM.0000000000001036.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - OBJECTIVE: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. RESULTS: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

AB - OBJECTIVE: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. RESULTS: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

KW - Adult Alloys/adverse effects Case-Control Studies Cause of Death Chemical Industry/statistics & numerical data Cobalt/adverse effects Cohort Studies Female Humans Lung Neoplasms/chemically induced/mortality Male Occupational Diseases/mortality Occupationa

U2 - 10.1097/jom.0000000000001036

DO - 10.1097/jom.0000000000001036

M3 - Article

SN - 1076-2752

VL - 59

SP - e275-e281

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 12

ER -

Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case-Control Studies

Abstract

Keywords

UN SDGs

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