MRI for the assessment of organ perfusion in patients with chronic kidney disease

Aghogho Odudu, Susan T. Francis, Christopher W. McIntyre

    Research output: Contribution to journalArticlepeer-review


    Purpose of Review: Recent data have highlighted the importance of quantitative measures of organ perfusion and functional reserve. Magnetic Resonance Imaging allows the assessment of markers of perfusion without the use of contrast media. Techniques such as arterial spin labelling (ASL) and blood oxygen level-dependent (BOLD) imaging have been available for some time, but advances in the technology and concerns over the safety of contrast media in renal disease have spurred renewed interest and development. Recent Findings: ASL measures perfusion, whereas BOLD imaging provides a marker of blood oxygenation, arising from the compound effect of a number of measures including perfusion, blood volume and oxygen consumption; thus, the techniques are complementary rather than analogous. They were initially confined to brain imaging as inherently low signal, susceptibility effects and motion limited their use in thoracic and abdominal organs. Advances in technology have led to robust sequences that can quantify clinically relevant changes and correlate well with reference standards. Novel approaches are likely to accelerate translation into clinical practice. Summary: The noninvasive and repeatable nature of ASL and BOLD imaging makes it likely that they will be increasingly used in clinical research. Using a developmental framework, we suggest that the application of these techniques to thoracic and abdominal organs requires validation before they are suitable for generalized clinical use. The demand for these techniques is likely to be driven by the incentive to avoid the use of contrast media. © 2012 Wolters Kluwer Health | Lippincott Williams and Wilkins.
    Original languageEnglish
    Pages (from-to)647-654
    Number of pages7
    JournalCurrent opinion in nephrology and hypertension
    Issue number6
    Publication statusPublished - Nov 2012


    • arterial spin labelling
    • blood oxygen level-dependent imaging
    • cardiac
    • flow-alternating inversion recovery
    • MRI
    • perfusion imaging
    • renal


    Dive into the research topics of 'MRI for the assessment of organ perfusion in patients with chronic kidney disease'. Together they form a unique fingerprint.

    Cite this